Elevated levels of growth-related hormones in autism and autism spectrum disorder
Elevated levels of growth-related hormones in autism and autism spectrum disorder
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DOI：
10.1111/j.1365-2265.2007.02868.x
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发表时间：
2007-08-01
影响因子：
3.2
通讯作者：
England, Lucinda J.
中科院分区：
文献类型：
--
作者：
Mills, James L.;Hediger, Mary L.;England, Lucinda J.
目的自闭症儿童的头围较大，但他们的身高和体重是否高于平均水平尚不清楚。此外，人们对自闭症儿童的生长相关激素水平知之甚少。我们调查了自闭症儿童是否更高更重，以及他们是否比对照组儿童有更高水平的生长相关激素。设计采用病例对照研究设计，在辛辛那提儿童医院对患有自闭症谱系障碍（ASD）或自闭症的男孩（n = 71）和年龄匹配的对照组男孩（n = 59）进行评估。测量身高、体重和头围。结果孤独症/ASD患者头围（平均z值1.24，标准差1.35）显著高于对照组（平均z值0.78，标准差0.93）（P = 0.03）。自闭症受试者的体重（平均z分数0.91，SD 1.13）也显著（P = 0.01）高于对照组（平均z分数0.41，SD 1.11）。两组之间的身高没有显著差异（P = 0.65）;自闭症/ASD受试者的体重指数（BMI）（平均z评分0.85，SD 1.19）显著（P = 0.003）高于对照组（平均z评分0.24，SD 1.17）。孤独症/ASD组IGF-1、IGF-2、IGFBP-3和GHBP水平均显著高于正常对照组（均P
Objective Children with autism are known to have larger head circumferences; whether they are above average in height and weight is less clear. Moreover, little is known about growth-related hormone levels in children with autism. We investigated whether children with autism were taller and heavier, and whether they had higher levels of growth-related hormones than control children did.Design A case-control study design was employed.Patients Boys with autism spectrum disorder (ASD) or autism (n = 71) and age-matched control boys (n = 59) were evaluated at Cincinnati Children's Hospital.Measurements Height, weight and head circumference were measured. Blood samples were assayed for IGF-1 and 2, IGFBP-3, growth hormone binding protein (GHBP) and for dehydroepiandrosterone (DHEA) and DHEA sulphate (DHEAS).Results Subjects with autism/ASD had significantly (P = 0.03) greater head circumferences (mean z-score 1.24, SD 1.35) than controls (mean z-score 0.78, SD 0.93). Subjects with autism also had significantly (P = 0.01) greater weights (mean z-score 0.91, SD 1.13) than controls (mean z-score 0.41, SD 1.11). Height did not differ significantly between groups (P = 0.65); subjects with autism/ASD had significantly (P = 0.003) higher body mass indices (BMI) (mean z-score 0.85, SD 1.19) than controls (mean z-score 0.24, SD 1.17). Levels of IGF-1, IGF-2, IGFBP-3 and GHBP in the group with autism/ASD were all significantly higher (all P