In vivo Delivery, Pharmacokinetics, Biodistribution and Toxicity of Iron Oxide Nanoparticles
In vivo Delivery, Pharmacokinetics, Biodistribution and Toxicity of Iron Oxide Nanoparticles
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DOI：
10.1002/chin.201601215
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
H. Arami;A. Khandhar;D. Liggitt;K. Krishnan
中科院分区：
文献类型：
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作者：
H. Arami;A. Khandhar;D. Liggitt;K. Krishnan
氧化铁纳米颗粒（IONP）在过去二十年中已被广泛使用，作为有效的生物成像造影剂或作为生物分子（如药物、核酸和肽）的载体用于控制递送到特定器官和组织。大多数这些新的应用需要精心调整的物理化学和表面性质的离子纳米粒子。随着新的IONP设计的设想，协同考虑身体对所施用的纳米颗粒的先天生物屏障以及IONP的短期和长期副作用变得更加重要。有几个重要的标准（如大小和大小分布，电荷，涂层分子，和血浆蛋白吸附），可以有效地调整，以控制在体内的药代动力学和生物分布的IONP。本文回顾了这些关键参数，在体内的生物屏障，以及最新的IONP设计策略，用于克服它们。还给出了与纳米颗粒设计有关的IONP的长期生物分布和副作用的仔细审查。虽然本综述中的讨论是针对IONP的，但其中一些信息可以很容易地应用于其他纳米颗粒系统，如金、银、二氧化硅、磷酸钙和各种聚合物。
Iron oxide nanoparticles (IONPs) have been extensively used during the last two decades, either as effective bio-imaging contrast agents or as carriers of biomolecules such as drugs, nucleic acids and peptides for controlled delivery to specific organs and tissues. Most of these novel applications require elaborate tuning of the physiochemical and surface properties of the IONPs. As new IONPs designs are envisioned, synergistic consideration of the body's innate biological barriers against the administered nanoparticles and the short and long-term side effects of the IONPs become even more essential. There are several important criteria (e.g. size and size-distribution, charge, coating molecules, and plasma protein adsorption) that can be effectively tuned to control the in vivo pharmacokinetics and biodistribution of the IONPs. This paper reviews these crucial parameters, in light of biological barriers in the body, and the latest IONPs design strategies used to overcome them. A careful review of the long-term biodistribution and side effects of the IONPs in relation to nanoparticle design is also given. While the discussions presented in this review are specific to IONPs, some of the information can be readily applied to other nanoparticle systems, such as gold, silver, silica, calcium phosphates and various polymers.