Chromatin insulators and cohesins
Chromatin insulators and cohesins
复制标题
DOI：
10.1038/embor.2008.46
复制
发表时间：
2008-04-01
期刊：
影响因子：
7.7
通讯作者：
Ohlsson, Rolf
中科院分区：
文献类型：
--
作者：
Goendoer, Anita;Ohlsson, Rolf
染色质绝缘子和粘着蛋白染色质绝缘子已经进化到通过使用在线性基因组上通常彼此远离的调节元件来调节转录。该特征是位置依赖性的，即功能性绝缘子必须位于增强子和其靶启动子之间（Wallace和Felsenfeld，2007）。绝缘的分子基础似乎与染色质纤维不同部分之间的几种长程物理相互作用紧密相关，并且可能依赖于这些作用（Wallace & Felsenfeld，2007）。这由H19印迹控制区例示，其不仅调节长程相互作用，而且调节关键顺式元件的表观遗传状态（Kurukuti等，2006）。独立的建议促进了这样的想法，即粘附素复合物的组分可能参与这种复合物的形成并有助于绝缘子功能（Hagstrom & Meyer，2003）。这一建议在最近几期《自然》杂志上发表的三篇开创性的报告中得到了部分证实（Wendt等人，
Chromatin insulators and cohesins chromatin insulators have evolved to regulate transcription by using regulatory elements that are often distant from each other on the linear genome. this feature is position-dependent—that is, a functional insulator must be positioned between the enhancer and its target promoter (Wallace & Felsenfeld, 2007). the molecular basis of insulation seems to be tightly linked to, and might depend on, several long-range physical interactions between different portions of the chromatin fibre (Wallace & Felsenfeld, 2007). this is exemplified by the H19 imprinting control region, which not only regulates long-range interactions but also the epigenetic states of a crucial cis element (Kurukuti et al, 2006). independent suggestions have promoted the idea that components of the cohesin complex might participate in the formation of such complexes and contribute to the insulator function (Hagstrom & Meyer, 2003). this proposal has been partly borne out in three seminal reports published in recent issues of Nature (Wendt et al,