ON THE SELECTIVITY OF DEPROTECTION OF BENZYL, MPM (4-METHOXYBENZYL) AND DMPM (3,4-DIMETHOXYBENZYL) PROTECTING GROUPS FOR HYDROXY FUNCTIONS
ON THE SELECTIVITY OF DEPROTECTION OF BENZYL, MPM (4-METHOXYBENZYL) AND DMPM (3,4-DIMETHOXYBENZYL) PROTECTING GROUPS FOR HYDROXY FUNCTIONS
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DOI：
10.1016/s0040-4020(01)90593-9
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发表时间：
1986-01-01
期刊：
影响因子：
2.1
通讯作者：
YONEMITSU, O
中科院分区：
文献类型：
--
作者：
HORITA, K;YOSHIOKA, T;YONEMITSU, O
在室温下，在含少量水的二氯甲烷中，4-甲氧基苄基(MPM)的羟基保护基团很容易被DDQ除去。在这些中性条件下，其他几个保护和官能团保持不变。3，4-二甲氧基苄基(DMPM)比MPM基团对DDQ的反应活性更强。以骨架镍为催化剂，通过催化加氢脱除了苯基(Bn)保护基。还给出了DMPM、MPM和Bn基团的选择性去保护。
The 4-methoxybenzyl (MPM) protecting group for hydroxyl functions is readily removed with DDQ in dichloromethane containing a small amount of water at room temperature. Under these neutral conditions, several other protecting and functional groups remained unchanged. 3,4-Dimethoxybenzyl (DMPM) groups are more reactive than MPM groups with DDQ. The benzyl (Bn) protecting group was removed by catalytic hydrogenation over Raney nickel. Selective deprotection of DMPM, MPM and Bn groups is also presented.