Immunolocalization of voltage-gated potassium channel Kv3.1b subunit in the cochlea
Immunolocalization of voltage-gated potassium channel Kv3.1b subunit in the cochlea
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耳蜗中电压门控钾通道 Kv3.1b 亚基的免疫定位
DOI：
10.1097/00001756-200108280-00033
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发表时间：
2001
期刊：
影响因子：
1.7
通讯作者：
Toshimitsu Kobayashi
中科院分区：
文献类型：
--
作者：
Eigo So;T. Kikuchi;K. Ishimaru;Yuka Miyabe;Toshimitsu Kobayashi
用免疫组织化学方法研究了电压门控性钾通道Kv3.1b亚基在耳蜗组织中的定位。Kv3.1b免疫反应阳性细胞分布于耳蜗侧壁I型、III型、IV型和纹状体上纤维细胞。牙间细胞、螺旋缘成纤维细胞及缘上暗细胞也有免疫染色。K+离子在内耳的机械感觉转导过程中起着关键作用，它通过耳蜗中的缝隙连接网络进行循环。这些结果提示，耳蜗侧壁成纤维细胞中含有Kv3.1b的电压门控性钾通道可能通过内耳的缝隙连接控制细胞内电位，在调节钾离子循环机制中发挥重要作用。
Immunohistochemical localization of voltage-gated potassium channel Kv3.1b subunit was studied in the cochlea. Intense Kv3.1b-like immunoreactivity was present in the type I, type III, type IV and suprastrial fibrocytes of the cochlear lateral wall. Immunostaining was also found in the interdental cells and the fibrocytes of the spiral limbus and in the supralimbal dark cells. K+ ions, which play a pivotal role in the mechanosensory transduc tion process in the inner ear, are recycled via gap junctional networks in the cochlea. These results suggest that the voltage-gated potassium channel, containing Kv3.1b, in the cochlear lateral wall fibrocytes may control the intracellular potential and play an important role in regulating the potassium ion recycling mechanism via gap junctions in the inner ear.