Determinants of coronary artery and aortic calcification in the old order amish
Determinants of coronary artery and aortic calcification in the old order amish
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DOI：
10.1161/circulationaha.106.637512
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发表时间：
2007-02-13
期刊：
影响因子：
37.8
通讯作者：
Mitchell, Braxton D.
中科院分区：
文献类型：
--
作者：
Post, Wendy;Bielak, Lawrence F.;Mitchell, Braxton D.
背景——冠状动脉钙化（CAC）与心血管疾病风险增加有关；然而，关于胸主动脉钙化（AC）知之甚少。我们的目标是描述CAC和AC的危险因素，并估计其变异的遗传贡献。方法和结果-通过电子束计算机断层扫描和空腹血液测试测量CAC和AC的存在和数量，并获得614名无症状阿米什受试者的心血管危险因素。男性的CAC患病率高于女性（55%对41%，P < 0.0001），尽管AC患病率没有性别差异（男性和女性分别为51%和56%，P = 0.95）。年龄与AC的存在（比值比[OR]， 5年为2.7）比CAC的存在（比值比[OR]， 5年为1.9）的相关性更强（同质性P = 0.001）。患有AC的受试者患CAC的几率高出3.3倍。CAC和AC存在的遗传力分别为0.27 +/- 0.17 （P = 0.04）和0.55 +/- 0.18 (P = 0.0008)，而CAC和AC数量的遗传力分别为0.30 +/- 0.10 （P = 0.001）和0.40 +/- 0.10 （P < 0.0001）。CAC与AC数量的遗传相关为0.34 +/- 0.19，环境相关为0.38 +/- 0.09。结论- CAC和AC具有相似的危险因素，除了男性性别仅与CAC相关，年龄与AC的相关性更强。相关性模式表明CAC和AC具有一些共同的基因和环境因素，尽管不同的基因和环境因素也可能影响每个部位的钙化。
Background - Coronary artery calcification (CAC) is associated with an increased risk of cardiovascular disease; little is known, however, about thoracic aortic calcification (AC). Our goal was to characterize risk factors for CAC and AC and to estimate the genetic contribution to their variation.Methods and Results - The presence and quantity of CAC and AC were measured with electron beam computed tomography and fasting blood tests and cardiovascular risk factors were obtained in 614 asymptomatic Amish subjects. CAC prevalence was higher in men than women (55% versus 41%; P < 0.0001), although there was no sex difference in AC prevalence (51% and 56% in men and women, respectively; P = 0.95). Age was more strongly associated with AC presence (odds ratio [OR], 2.7 for 5 years) than CAC presence (OR, 1.9 for 5 years) (homogeneity P = 0.001). Subjects with AC had a 3.3- fold higher odds of having CAC. Heritabilities of CAC and AC presence were 0.27 +/- 0.17 (P = 0.04) and 0.55 +/- 0.18 (P = 0.0008), respectively, whereas the heritabilities of quantity of CAC and AC were 0.30 +/- 0.10 (P = 0.001) and 0.40 +/- 0.10 (P < 0.0001), respectively. The genetic correlation between CAC and AC quantity was 0.34 +/- 0.19, whereas the environmental correlation between these 2 traits was 0.38 +/- 0.09.Conclusions - CAC and AC have similar risk factors, except male gender is associated only with CAC and age is more strongly associated with AC. The patterns of correlations suggest that CAC and AC share some common sets of genes and environmental factors, although it is likely that separate genes and environmental factors also influence calcification at each site.