Simulation of hemodynamics and regulatory mechanisms in the cardiovascular system based on a nonlinear and time-varying model
Simulation of hemodynamics and regulatory mechanisms in the cardiovascular system based on a nonlinear and time-varying model
复制标题
基于非线性时变模型的心血管系统血流动力学和调节机制模拟
DOI：
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发表时间：
1992
期刊：
影响因子：
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通讯作者：
S. Chiaramida
中科院分区：
文献类型：
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作者：
Ying Sun;S. Chiaramida
开发了模拟心血管系统压力-流量关系和调节机制的软件。该软件的核心是一组状态方程，其基于模拟电模型表征心血管动力学。通过数值积分，时间步长为1 ms，状态在时间上向前传播。通过每5 ms更新一次状态方程，在模拟中处理非线性和时变元素。每个心动周期的血液动力学波形被平均并用作循环调节的几个模型的输入。研究中的调节机制包括系统性自身调节、颈动脉压力感受器反射和心肌内钙离子积聚对左心室收缩力的影响。结果表明，模拟准确地代表了心血管动力学和生理学的几个观察。该软件对于发展体内研究的假设和方案，整合和解释实验结果，以及作为计算机辅助教学的工具，应该是有价值的。
Software is developed to simulate pressure- flow relationships and regulatory mecha nisms in the cardiovascular system. The core of the software is a set of state equations that characterizes the cardiovascular dynamics based on an analog electrical model. The state is propagated forward in time by numerical integration with a time step of 1 ms. Nonlinear and time-varying elements are treated in the simulation by updating the state equations every 5 ms. Hemodynamic waveforms from each cardiac cycle are averaged and used as input to several models of circulatory regulation. The regulatory mechanisms under investigation include the systemic autoregulation, the carotid baroreflex, and the effect of intramyocardial accumulation of calcium ions on left ventricular contractility. It is shown that the simulation accurately represents several observations of the cardiovascular dynamics and physiology. The software should be valuable for develop ing hypotheses and protocols of in vivo studies, for integrating and interpreting experimental results, and as a tool of computer aided instruction.