Frontotemporal dementia: Behavioral symptoms and caregiver distress
Frontotemporal dementia: Behavioral symptoms and caregiver distress
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DOI：
10.1159/000080123
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发表时间：
2004-01-01
影响因子：
2.4
通讯作者：
Tibben, A
中科院分区：
文献类型：
--
作者：
Mourik, JC;Rosso, SM;Tibben, A
目的：了解额颞叶痴呆（FTD）患者共同出现的行为问题，并探讨行为聚类与照顾者负担的关系。患者和方法：采用63例FTD患者及其护理者的基线数据，检测神经精神量表（NPI）中的行为聚类以及护理者所引发的伴随困扰。为了检测FTD患者行为中的群集，我们进行了多维缩放（程序：PROXSCAL）。采用多元回归分析来确定患者行为与护理人员所经历的痛苦之间的关系。结果：这是首次发现FTD的行为集群的研究。研究发现了两类行为：躁动/精神病（包括妄想、幻觉、易怒和躁动）和情绪（由焦虑和抑郁组成）。其余的NPI域（欣快感、去抑制、异常运动行为和冷漠）是自主的。在控制相关混杂因素后，照顾者苦恼与躁动/精神病的关系最强，其次是情绪。抑制解除和异常运动行为与照顾者痛苦轻度相关。欣快感和冷漠与痛苦无显著相关。家庭护理人员对FTD患者行为问题的焦虑程度高于住院护理人员。讨论：本研究证实了FTD患者中精神病理的高患病率以及相关的照顾者困扰。聚类行为症状允许研究结构或功能性脑缺陷与神经精神症状之间的关系。版权所有(C) 2004 S. Karger AG，巴塞尔。
Objective: To discern behavioral problems that co-occur in frontotemporal dementia (FTD) patients, and to investigate the relation between behavioral clusters and the burden for caregivers. Patients and Methods: Baseline data of 63 FTD patients and their respective caregivers were used to detect the behavioral clusters in the Neuropsychiatric Inventory (NPI) and the accompanying distress evoked in caregivers. To detect the clusters in behavior of the FTD patients, we performed multidimensional scaling (procedure: PROXSCAL). Multiple regression analysis was used to determine the association between behavior of patients and the distress experienced by caregivers. Results: This was the first study that found behavioral clusters for FTD. Two behavioral clusters were found: agitation/psychosis ( comprising delusions, hallucinations, irritability and agitation) and mood ( made up of anxiety and depression). The remaining NPI domains ( euphoria, disinhibition, aberrant motor behavior and apathy were found to be autonomous. After controlling for relevant confounding factors, caregiver distress was strongest related to agitation/psychosis, followed by mood. Disinhibition and aberrant motor behavior were mildly related to caregiver distress. Euphoria and apathy were not significantly related to distress. Caregivers of patients living at home were more distressed by the behavioral problems of the FTD patients than caregivers of hospitalized patients. Discussion: The high prevalence of psychopathology in FTD patients and the associated caregiver distress was confirmed in this study. Clustering behavioral symptoms allows investigation of the relationship between structural or functional cerebral deficits and neuropsychiatric symptoms. Copyright (C) 2004 S. Karger AG, Basel.