ROLE OF PYRIDOXINE IN GLUTATHIONE METABOLISM
ROLE OF PYRIDOXINE IN GLUTATHIONE METABOLISM
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DOI：
10.1042/bj0900060
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发表时间：
1964-01-01
影响因子：
4.1
通讯作者：
BUDDEMEYER, E
中科院分区：
文献类型：
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作者：
HSU, JM;CHOW, BF;BUDDEMEYER, E
在大鼠中研究了在各种饮食方案下诱导的吡哆醇缺乏对红细胞和组织中非蛋白SH化合物（主要是GSH）谷胱甘肽浓度的影响。吡哆醇缺乏导致红细胞和肝脏中GSH浓度升高，但肾脏、脾脏和脑中GSH浓度不升高。当吡哆醇缺乏的大鼠接受不含半胱氨酸或谷氨酸的饮食时，也观察到肝脏中GSH浓度的增加。[2-C14]甘氨酸和[1-C14]谷氨酸掺入GSH部分的吡哆醇缺乏增强。提示吡哆醇是谷胱甘肽代谢的重要调节剂。
The effect of pyridoxine deficiency induced under various dietary regimens, on the concentration of non-protein SH compounds (essentially GSH) glutathione in erythrocytes and tissues was studied in rats. Deficiency of pyridoxine resulted in an elevation of GSH concentrations in erythrocytes and liver, but not in kidneys, spleen and brain. An increase of GSH concentration in liver was also observed when pyridoxine-deficient rats received a diet free of cysteine or glutamic acid. The incorporation of [2-C14]glycine and [1-C14]glutamic acid into the GSH moiety was enhanced by pyridoxine deficiency. It is suggested that pyridoxine is an important regulator in glutathione metabolism.