Physical activity and mortality in postmenopausal women
Physical activity and mortality in postmenopausal women
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DOI：
10.1001/jama.277.16.1287
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发表时间：
1997-04-23
影响因子：
120.7
通讯作者：
Sellers, TA
中科院分区：
文献类型：
--
作者：
Kushi, LH;Fee, RM;Sellers, TA
客观。-评估体力活动与绝经后妇女全因死亡率之间的关系。前瞻性队列研究，随访7年，至1992年12月31日。受试者为40417名绝经后爱荷华州妇女，1986年基线年龄为55 - 69岁。体力活动通过邮寄问卷进行评估。全因死亡率（n=2260）。在调整潜在的混杂因素并排除报告患有癌症或心脏病的女性以及在随访的前3年内死亡的女性后，报告定期体力活动的女性在随访期间的死亡风险显著低于没有报告的女性（相对风险[RR]，0.77; 95%置信区间[CI]，0.66-0.90）。增加中度体力活动的频率与随访期间死亡风险的降低相关（从很少或从不参加活动到每周至少活动4次，RR，1.0 [参考]，0.76，0.70和0.62;趋势P值<0.001）。在剧烈体力活动中观察到类似的模式（相应的RR为1.0、0.89、0.74和0.57;趋势P值= 0.06）。心血管疾病（n = 729）和呼吸系统疾病（n = 147）的死亡风险随着体力活动的增加而明显降低。仅从事中度但不剧烈体力活动的女性也受益，每周一次的中度活动表明死亡风险降低了0.78（95% CI，0.64-0.96）。这些结果表明，体力活动和绝经后妇女的全因死亡率之间存在分级的负相关。这些发现增强了人们对绝经后妇女进行定期体力活动的建议的信心。
Objective.-To evaluate the association between physical activity and all-cause mortality in postmenopausal women.Design.-Prospective cohort study with 7 years of follow-up through December 31, 1992.Setting and Participants.-Subjects were 40 417 postmenopausal Iowa women, aged 55 to 69 years at baseline in 1986. Physical activity was assessed by mailed questionnaire.Main Outcome Measure.-All-cause mortality (n=2260).Results.-After adjustment for potential confounders and excluding women who reported having cancer or heart disease and those who died in the first 3 years of follow-up, women who reported regular physical activity were at significantly reduced risk of death during follow-up compared with women who did not (relative risk [RR], 0.77; 95% confidence interval [CI], 0.66-0.90). Increasing frequency of moderate physical activity was associated with reduced risk of death during followup (from rarely or never engaging in activity to activity at least 4 times per week, RRs, 1.0 [referent], 0.76, 0.70, and 0.62; P value for trend < .001). A similar pattern was seen for vigorous physical activity (corresponding RRs, 1.0, 0.89, 0.74, and 0.57; P value for trend = .06). Reduced risks of death with increased physical activity were evident for cardiovascular diseases (n = 729) and respiratory illnesses (n = 147). Women who engaged only in moderate but not vigorous physical activity also benefited, with moderate activity as infrequently as once per week demonstrating a reduced mortality risk of 0.78 (95% CI, 0.64-0.96).Conclusions.-These results demonstrate a graded, inverse association between physical activity and all-cause mortality in postmenopausal women. These findings strengthen the confidence that population recommendations to engage in regular physical activity are applicable to postmenopausal women.