The use and abuse of commercial kits used to detect autoantibodies.
The use and abuse of commercial kits used to detect autoantibodies.
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DOI：
10.1186/ar782
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发表时间：
2003
影响因子：
4.9
通讯作者：
Barr SG
中科院分区：
文献类型：
--
作者：
Fritzler MJ;Wiik A;Fritzler ML;Barr SG
人血清中自身抗体的检测是诊断和管理自身免疫性疾病患者的重要方法。为了满足市场需求，制造商已经开发了各种各样的易于使用且具有成本效益的诊断试剂盒，其被设计用于检测各种人血清自身抗体。过去20年的大量研究表明，商业试剂盒的检测结果在使用和临床应用中存在局限性和问题。重要的是要认识到，有一个复杂的用户链和环境，有助于商业试剂盒的明显可靠性的变化。这次审查的目的是查明这一链条中的主要环节，查明削弱这一链条的因素，并提出解决方案。建议所有参与者之间需要更高水平的承诺和伙伴关系，以实现通过使用自身抗体检测和分析提高患者护理质量的目标。
The detection of autoantibodies in human sera is an important approach to the diagnosis and management of patients with autoimmune conditions. To meet market demands, manufacturers have developed a wide variety of easy to use and cost-effective diagnostic kits that are designed to detect a variety of human serum autoantibodies. A number of studies over the past two decades have suggested that there are limitations and concerns in the use and clinical application of test results derived from commercial kits. It is important to appreciate that there is a complex chain of users and circumstances that contributes to variations in the apparent reliability of commercial kits. The goal of this review is to identify the principal links in this chain, to identify the factors that weaken the chain and to propose a plan of resolution. It is suggested that a higher level of commitment and partnership between all of the participants is required to achieve the goal of improving the quality of patient care through the use of autoantibody testing and analysis.