New Insights Into Tissue Macrophages: From Their Origin to the Development of Memory.
New Insights Into Tissue Macrophages: From Their Origin to the Development of Memory.
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DOI：
10.4110/in.2015.15.4.167
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发表时间：
2015-08
期刊：
影响因子：
6
通讯作者：
Boraschi D
中科院分区：
文献类型：
--
作者：
Italiani P;Boraschi D
巨噬细胞是天然免疫的主要效应细胞，参与炎症和抗感染过程。它们还在维持组织稳态、支持组织发育和修复组织损伤方面发挥重要作用。直到几年前，人们认为组织巨噬细胞来源于循环血液单核细胞，其在组织中终末分化并且不能增殖。组织巨噬细胞生物学的最新证据揭示了一系列长期被忽视的免疫和个体发育特征，尽管有旧的观察结果。这些包括起源，异质性，增殖潜力（或自我更新），极化和记忆。近年来，关于组织驻留巨噬细胞的出版物数量迅速增长，突出了免疫学家对这些先天免疫关键参与者的新兴趣。这篇简短的综述旨在总结巨噬细胞免疫生物学的最新知识，以提供该领域的清晰和即时的概述。
Macrophages are the main effector cells of innate immunity and are involved in inflammatory and anti-infective processes. They also have an essential role in maintaining tissue homeostasis, supporting tissue development, and repairing tissue damage. Until few years ago, it was believed that tissue macrophages derived from circulating blood monocytes, which terminally differentiated in the tissue and unable to proliferate. Recent evidence in the biology of tissue macrophages has uncovered a series of immune and ontogenic features that had been neglected for long, despite old observations. These include origin, heterogeneity, proliferative potential (or self-renewal), polarization, and memory. In recent years, the number of publications on tissue resident macrophages has grown rapidly, highlighting the renewed interest of the immunologists for these key players of innate immunity. This mini-review aims to summarizing the new current knowledge in macrophage immunobiology, in order to offer a clear and immediate overview of the field.