Micrococcus luteus cells and cell walls induce anaphylactoid reactions accompanied by early death and serum cytokines in mice primed with muramyl dipeptide
Micrococcus luteus cells and cell walls induce anaphylactoid reactions accompanied by early death and serum cytokines in mice primed with muramyl dipeptide
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DOI：
10.1016/s0928-8244(96)00104-6
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发表时间：
1997-01-01
影响因子：
--
通讯作者：
Takada, H
中科院分区：
文献类型：
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作者：
Monodane, T;Kawabata, Y;Takada, H
在用胞壁酰二肽（MDP，100 μ g）致敏的C3 H/HeN小鼠中，500 μ g全细胞剂量的藤黄微球菌菌株引起过敏样反应，在某些情况下在1小时内导致死亡。分别在半数和全部存活小鼠的血清中诱导肿瘤坏死因子（TNF）和白细胞介素-6（IL-6）。M.迄今为止所研究的黄体病毒也引起伴随着早期死亡的过敏样反应，并且一种菌株诱导高水平的TNF和IL-6。细胞质膜也诱导IL-6。用代表性的M.黄体细胞和细胞壁标本。这些结果表明M.黄体具有与诱导败血性休克和全身性炎性疾病相关的毒力活性。
Micrococcus luteus strains at a dose of 500 mu g of whole cells caused anaphylactoid reactions leading to death in some instances within 1 h in C3H/HeN mice primed with muramyl dipeptide (MDP, 100 mu g). Tumor necrosis factor (TNF) and interleukin-6 (IL-6) were induced in the serum of half and of all the surviving mice, respectively. Cell wall specimens of M. luteus so far examined also caused anaphylactoid reactions accompanied by early death and one strain induced high levels of TNF and IL-6. Cytoplasmic membranes also induced IL-6. Essentially similar results were obtained with representative M. luteus cells and a cell wall specimen in MDP-primed C3H/HeJ mice. These results indicate that M. luteus has virulence activities that are associated with the induction of septic shock and systemic inflammatory diseases.