Morphogenesis and maturation of the embryonic and postnatal intestine.
Morphogenesis and maturation of the embryonic and postnatal intestine.
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DOI：
10.1016/j.semcdb.2017.01.011
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发表时间：
2017-06
影响因子：
7.3
通讯作者：
Spence JR
中科院分区：
文献类型：
--
作者：
Chin AM;Hill DR;Aurora M;Spence JR
肠道是负责营养吸收、胆汁和废物排泄的重要器官，也是宿主免疫的主要场所。为了满足日常需求，肠道已经进化出一种机制，通过经历形态发生过程来扩大吸收表面积，以产生称为绒毛的指状单位。这些绒毛容纳专门的细胞类型，这些细胞类型对于从食物中吸收营养和保护宿主免受成人肠道中存在的寄生虫和病原微生物的侵害至关重要。在这篇综述中，我们将讨论协调肠道发育，生长和小肠成熟的机制，从早期肠管的形成开始，通过绒毛形态发生，到出生后早期，肠道必须适应通过食物摄入获得营养物质，并与微生物相互作用。
The intestine is a vital organ responsible for nutrient absorption, bile and waste excretion, and a major site of host immunity. In order to keep up with daily demands, the intestine has evolved a mechanism to expand the absorptive surface area by undergoing a morphogenetic process to generate finger-like units called villi. These villi house specialized cell types critical for both absorbing nutrients from food, and for protecting the host from commensal and pathogenic microbes present in the adult gut. In this review, we will discuss mechanisms that coordinate intestinal development, growth, and maturation of the small intestine, starting from the formation of the early gut tube, through villus morphogenesis and into early postnatal life when the intestine must adapt to the acquisition of nutrients through food intake, and to interactions with microbes.