Uveal melanoma: epidemiologic aspects.
Uveal melanoma: epidemiologic aspects.
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DOI：
10.1016/j.ohc.2004.07.002
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发表时间：
2005-03-01
期刊：
影响因子：
--
通讯作者：
Seregard, Stefan
中科院分区：
文献类型：
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作者：
Singh, Arun D;Bergman, Louise;Seregard, Stefan
眼和附属器结构的黑色素瘤约占所有黑色素瘤的5%。大多数（85%）的眼部黑色素瘤起源于葡萄膜;原发性结膜和眼眶黑色素瘤是罕见的。葡萄膜黑色素瘤的诊断是通过临床检查，包括间接检眼镜和辅助研究，如荧光素血管造影和超声检查。大约50%的后葡萄膜黑色素瘤患者在初次诊断和治疗后15年内发生肝转移;然而，在初次就诊时临床上明显的转移性疾病并不常见，这表明在大多数情况下存在早期亚临床转移。
Melanomas of the ocular and adnexal structures comprise approximately 5% of all melanomas. The majority (85%) of ocular melanomas are uveal in origin; primary conjunctival and orbital melanomas are rare. The diagnosis of uveal melanoma is made by clinical examination including indirect ophthalmoscopy and by ancillary studies such as fluorescein angiography and ultrasonography. Metastases to the liver develop within 15 years after the initial diagnosis and treatment in approximately 50% of patients with posterior uveal melanoma; however, clinically evident metastatic disease at the time of initial presentation is uncommon, indicating that there is early subclinical metastasis in most cases.