Effect of Tenofovir With and Without Interferon on Hepatitis D Virus Replication in HIV-Hepatitis B Virus-Hepatitis D Virus-Infected Patients
Effect of Tenofovir With and Without Interferon on Hepatitis D Virus Replication in HIV-Hepatitis B Virus-Hepatitis D Virus-Infected Patients
复制标题
DOI：
10.1089/aid.2013.0008
复制
发表时间：
2013-12-01
影响因子：
1.5
通讯作者：
Lacombe, Karine
中科院分区：
文献类型：
--
作者：
Boyd, Anders;Miailhes, Patrick;Lacombe, Karine
替诺福韦（TDF）单独或与干扰素联合对丁型肝炎病毒（HDV）复制的影响在感染人类免疫缺陷病毒（HIV）、B型肝炎病毒（HBV）和HDV的患者中的特征不明显。我们分析了接受单独TDF治疗（n=13）或在TDF治疗期间的某个时间点包括干扰素（IFN）治疗（TDF+IFN，n=4）的三重感染患者。使用线性混合效应模型估计治疗期间HDV-RNA和肝炎表面抗原（HBsAg）水平较基线的平均变化。患者随访时间中位数为31.6（25-75%-tile：15.0-47.4）个月。在TDF+IFN组中，3名患者在接受拉米夫定（LAM）+TDF治疗的中位时间为21.7个月（范围=10.5-24.9）后开始了以IFN为基础的治疗，而其余患者既往接受了46.8个月的LAM治疗。在两组中均观察到HDV-RNA显著降低[单独TDF：-0.380 log（10）拷贝/ml/年（95% CI：-0.557，-0.202）vs. TDF+IFN：-1.325 log（10）拷贝/ml每年（95% CI：-1.931，-0.720）]，而HDV-RNA下降总体上在TDF+IFN患者中显著更快（p=0.002）。因此，两名患者获得的HDV-RNA低于定量限（LOQ：
The effect of tenofovir (TDF) alone or in combination with interferon on hepatitis D virus (HDV) replication is poorly characterized in patients infected with human immunodeficiency virus (HIV), hepatitis B virus (HBV), and HDV. We analyzed triinfected patients undergoing treatment with either TDF alone (n=13) or including interferon (IFN) at some point during TDF therapy (TDF+IFN, n=4). Linear mixed-effect models were used to estimate the mean change from baseline of HDV-RNA and hepatitis surface antigen (HBsAg) levels during treatment. Patients were followed for a median 31.6 (25-75%-tile: 15.0-47.4) months. In the TDF+IFN group, three initiated IFN-based therapy after a median of 21.7 months (range=10.5-24.9) of lamivudine (LAM)+TDF, while the remaining patient had 46.8 months of prior LAM exposure. Significant decreases in HDV-RNA were observed in both groups [TDF alone: -0.380 log(10) copies/ml per year (95% CI: -0.557, -0.202) vs. TDF+IFN: -1.325 log(10) copies/ml per year (95% CI: -1.931, -0.720)], while the HDV-RNA decline overall was significantly faster in patients with TDF+IFN (p=0.002). Accordingly, two patients achieved HDV-RNA below the limit of quantification (LOQ: