DORIDOSINE - NEW HYPOTENSIVE N-METHYLPURINE RIBOSIDE FROM THE NUDIBRANCH ANISODORIS-NOBILIS
DORIDOSINE - NEW HYPOTENSIVE N-METHYLPURINE RIBOSIDE FROM THE NUDIBRANCH ANISODORIS-NOBILIS
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DOI：
10.1126/science.7350655
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发表时间：
1980-01-01
期刊：
影响因子：
56.9
通讯作者：
MOSHER, HS
中科院分区：
文献类型：
--
作者：
FUHRMAN, FA;FUHRMAN, GJ;MOSHER, HS
从裸目动物的消化腺中分离到一种新的甲基嘌呤核苷，可能为N1-甲基异鸟苷。多利多辛可使麻醉大鼠持续低血压和心动过缓，降低豚鼠体外心房收缩速度和收缩幅度，使麻醉小鼠心率减慢50%，数小时后动物完全恢复。
A newN-methylpurine riboside (doridosine), probablyN1-methylisoguanosine, was isolated from the digestive glands of a nudibranch. Doridosine produces prolonged hypotension and bradycardia in anesthetized rats, decreases the rate and the amplitude of contraction of guinea pig atria in vitro, and causes the heart rate in anesthetized mice to be reduced by 50 percent for many hours after which the animals recover completely.