Interleukin-6 and C-Reactive Protein Levels and 9-Year Cognitive Decline in Community-Dwelling Older Women: The Women's Health and Aging Study II
Interleukin-6 and C-Reactive Protein Levels and 9-Year Cognitive Decline in Community-Dwelling Older Women: The Women's Health and Aging Study II
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DOI：
10.1093/gerona/glu132
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发表时间：
2015-07-01
影响因子：
5.1
通讯作者：
Carlson, Michelle C.
中科院分区：
文献类型：
--
作者：
Palta, Priya;Xue, Qian-Li;Carlson, Michelle C.
背景。炎症升高是慢性疾病与认知功能障碍相关的一种被提出的机制。本研究的目的是验证这样一种假设，即在认知能力完好的社区老年妇女中，炎症水平越高，白细胞介素-6 （IL-6）和c反应蛋白的测量结果与认知能力下降的速度越快有关。我们分析了来自妇女健康和老龄化研究II的336名妇女。在基线和每18-36个月进行一次认知评估，包括以下领域：即时和延迟记忆（霍普金斯语言学习测试），精神运动速度（轨迹制造测试，部分A）和执行功能（轨迹制造测试，部分B）。IL-6和c -反应蛋白的综合测量，基于平均访问一次和二次，分类分析。采用随机效应模型检验9年来各炎症标志物的分位数与认知领域评分变化的关系。中等和高水平的IL-6预测精神运动速度的早期下降，每年1.0连接/分钟。在记忆或执行功能中，基线得分或IL-6的变化率没有差异。c -反应蛋白在所有认知领域中没有差异。血清IL-6水平越高，9年内精神运动速度下降越严重。这一发现可能表明，升高的IL-6可能导致微血管改变，从而导致沿神经元轴突排列的髓鞘受损，导致神经元繁殖减少和处理速度受损；然而，需要进行机制研究来评估这些假设。
Background. Elevated inflammation is a proposed mechanism relating chronic diseases to cognitive dysfunction. The objective of this study was to test the hypothesis that greater levels of inflammation, as measured by the proinflammatory cytokine interleukin-6 (IL-6) and C-reactive protein, are associated with faster rates of cognitive decline among cognitively intact community-dwelling older women.Methods. We analyzed 336 women from the Women's Health and Aging Study II. Cognitive assessments were performed at baseline and every 18-36 months, and included the following domains: immediate and delayed memory (Hopkins Verbal Learning Test), psychomotor speed (Trail Making Test, Part A), and executive function (Trail Making Test, Part B). Aggregate measures of IL-6 and C-reactive protein, based on the average from visits one and two, were analyzed categorically. Random effects models were employed to test the relationship between tertiles of each inflammatory marker and changes in cognitive domain scores over 9 years.Results. Moderate and high levels of IL-6 predicted early declines in psychomotor speed by 1.0 connection/min per year. There were no differences in baseline scores or rates of change across tertiles of IL-6 in memory or executive function. No differences were observed across tertiles of C-reactive protein for all cognitive domains.Conclusions. Higher levels of serum IL-6 were associated with greater declines in psychomotor speed over 9 years. This finding could suggest that elevated IL-6 may result in microvascular changes that may lead to damage of myelin sheaths that line neuronal axons, leading to decreased neuron propagation and impaired processing speed; however, mechanistic studies are needed to evaluate these hypotheses.