Performance on the Wisconsin Card Sorting Test in Families of Schizophrenia Patients With Different Familial Loadings
Performance on the Wisconsin Card Sorting Test in Families of Schizophrenia Patients With Different Familial Loadings
复制标题
DOI：
10.1093/schbul/sbs141
复制
发表时间：
2013-05-01
影响因子：
6.6
通讯作者：
Chen, Wei J.
中科院分区：
文献类型：
--
作者：
Lin, Sheng-Hsiang;Liu, Chih-Min;Chen, Wei J.
Despite the consistent presence of performance deficits on the Wisconsin Card Sorting Test (WCST) in schizophrenia patients, whether poorer performance is also present in their nonpsychotic relatives is not certain. This study aimed to estimate both the recurrence risk ratio (lambda s) and the heritability of WCST scores in simplex and multiplex families, respectively, and to examine the influence of familial loading on these estimates. Participants were patients with schizophrenia and their nonpsychotic first-degree relatives from 168 simplex families and 653 multiplex families as well as 440 normal comparisons. On the basis of adjusted Z scores, both the lambda s at a series of cutoff points and heritability estimates based on variance component modeling in the nonpsychotic relatives of schizophrenia patients were estimated. The WCST deficits in schizophrenia patients were more prominent in multiplex families than in simplex ones. Among relatives, WCST deficits were limited to parents of multiplex families for most WCST scores and siblings from multiplex families for total errors, perseverative responses, and perseverative errors. Pertaining to lambda s, the estimates for multiplex families (highest estimates ranging from 7.9 to 11.0) were greater than those for simplex ones (
