Zinc-finger transcription factor Gfi-1: versatile regulator of lymphocytes, neutrophils and hematopoietic stem cells
Zinc-finger transcription factor Gfi-1: versatile regulator of lymphocytes, neutrophils and hematopoietic stem cells
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DOI：
10.1097/01.moh.0000190111.85284.8f
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发表时间：
2006-01-01
影响因子：
3.2
通讯作者：
Orkin, SH
中科院分区：
文献类型：
--
作者：
Hock, H;Orkin, SH
审查的目的。 Gfi-1 最初被认为是淋巴细胞中的转录抑制因子，现在被认为在中性粒细胞成熟和造血干细胞生物学中具有重要的独立功能。在这里，我们回顾了有关 Gfi-1 及其在造血发育中细胞背景特定功能的最新研究。最新发现。在绘制造血发育过程中骨髓转录因子需求的精确时间方面的进展揭示了其作用序列的更精细的图景。我们将 Gfi-1 在中性粒细胞发育中的作用与 PU.1、C/EBP α 和 C/EBP epsilon 进行了对比。 Gfi-1已被发现是成体造血干细胞的主要调节因子。它是限制造血干细胞增殖并维持其功能完整性所必需的。我们讨论了它的作用，并将其功能与最近涉及造血干细胞生物学的其他调节器的功能进行了比较。总结。在理解 Gfi-1 在造血分化的特定阶段的上下文相关作用方面已经取得了相当大的进展。
Purpose of review. Gfi-1, originally identified as a transcriptional repressor in lymphoid cells, is now recognized to have essential, independent functions in neutrophil maturation and hematopoietic stem cell biology. Here we review recent studies pertaining to Gfi-1 and its cell context specific functions in hematopoietic development.Recent findings. Progress in mapping the precise timing of requirements for myeloid transcription factors during hematopoietic development reveals a more refined picture of their sequence of action, We contrast Gfi-1's role in neutrophil development with PU.1, C/EBP alpha, and C/EBP epsilon. Gfi-1 has been found to be a major regulator of adult hematopoietic stem cells. It is required for restricting the proliferation of hematopoietic stem cells and maintaining their functional integrity. We discuss its role and compare its function with that of other regulators recently implicated in the biology of hematopoietic stem cells.Summary. Considerable progress has been made in understanding Gfi-1's context-sensitive roles at defined stages of hematopoietic differentiation.