Effects of an intensive lifestyle intervention and the role of sleep in people living with HIV and prediabetes: a pilot and feasibility study.
Effects of an intensive lifestyle intervention and the role of sleep in people living with HIV and prediabetes: a pilot and feasibility study.
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强化生活方式干预的影响和睡眠在艾滋病毒感染者和前驱糖尿病患者中的作用：试点和可行性研究
DOI：
10.1186/s13104-021-05558-z
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发表时间：
2021-04-17
影响因子：
1.8
通讯作者：
Reutrakul S
中科院分区：
文献类型：
--
作者：
Nimitphong H;Sungkanuparph S;Areevut C;Saetung S;Jerawatana R;Hathaidechadusadee A;Somwang S;Tongchom W;Saibuathong N;Sakmanarit J;Pichitchaipitak O;Phuphuakrat A;Reutrakul S
糖尿病前期在艾滋病毒携带者(PLWH)中很常见。睡眠不足和不规律与糖代谢异常有关。这项研究旨在调查患有和不患有糖尿病前期的PLWH患者的睡眠特征的差异，确定为期六个月的生活方式强化干预(ILI)试点计划对糖尿病前期患者的糖代谢的可接受性/可行性和效果，并确定睡眠如何调节这些影响。39例PLWH患者(20例血糖正常，19例糖尿病前期)参与研究。正常血糖患者和糖尿病前期患者的睡眠特征没有差异。接下来，13名糖尿病前期患者完成了为期6个月的ILI计划。ILI计划在6个月时显著减轻了体重(63.5 ± 13.9至61.9 ± 14.0 kg，p = 0.012)，并维持在12个月(p <； 0.001)。12个月时腰围明显减少(85.4 ± 11.7to 82.9 ± 12.7cmp = 0.014)。睡眠变异性的增加与2小时血糖的增加显著相关，与体重指数的变化无关(b = 0.603)，与体力活动(b = 0.774)无关。这项初步研究表明，在糖尿病前期的PLWH患者中，ILI在改善代谢控制方面是可行和有效的，其效果可能受睡眠变化的调节。这些发现应该在一项更大规模的研究中得到证实，以降低这一人群中的糖尿病风险。试验报名：ClinicalTrial.gov，NCT03545217(报名日期：2018年5月22日)
Prediabetes is prevalent in people living with HIV (PLWH). Insufficient and irregular sleep are linked to abnormal glucose metabolism. This study aimed to investigate the differences in sleep characteristics between PLWH with and without prediabetes, determine the acceptability/feasibility and effects of a pilot six-month intensive lifestyle intervention (ILI) program on glucose metabolism in those with prediabetes, and determine how sleep modulates these effects. Thirty-nine PLWH (20 normoglycemia and 19 prediabetes) participated. There were no differences in sleep characteristics between individuals with normoglycemia and prediabetes. Next, thirteen individuals with prediabetes completed a six-month ILI program. The ILI program resulted in significant body weight reduction at 6 months (63.5 ± 13.9 to 61.9 ± 14.0 kg, p = 0.012), which was maintained at 12 months (p < 0.001). Waist circumferences were significantly decreased at 12 months (85.4 ± 11.7 to 82.9 ± 12.7 cm, p = 0.014). An increase in sleep variability was significantly associated with an increase in 2-h plasma glucose, independent of changes in BMI (b = 0.603), and physical activity (b = 0.774). This pilot study suggested that ILI in PLWH with prediabetes is feasible and effective in improving metabolic control, with its effects possibly modulated by sleep variability. These findings should be confirmed in a larger study to reduce diabetes risk in this population. Trail registration: ClinicalTrial.gov, NCT03545217 (date of registration: May 22, 2018)
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影响因子：
158.5
作者：
Knowler, WC;Barrett-Connor, E;Nathan, DM
通讯作者：
Nathan, DM
DOI：
10.1038/nrendo.2011.151
发表时间：
2011-09-20
期刊：
Nature reviews. Endocrinology
影响因子：
--
作者：
通讯作者：
--
影响因子：
4.6
作者：
Huang X;Li H;Meyers K;Xia W;Meng Z;Li C;Bai J;He S;Cai W;Huang C;Liu S;Wang H;Ling X;Ma P;Tan D;Wang F;Ruan L;Zhao H;Wei H;Liu Y;Yu J;Lu H;Wang M;Zhang T;Chen H;Wu H
通讯作者：
Wu H
影响因子：
3.5
作者：
Duncan, A. D.;Peters, B. S.;Goff, L. M.
通讯作者：
Goff, L. M.
影响因子：
4.9
作者：
Kjeldsen, J. S.;Hjorth, M. F.;Sjodin, A.
通讯作者：
Sjodin, A.