Predictive Value of Mild Cognitive Impairment for Dementia The Influence of Case Definition and Age
Predictive Value of Mild Cognitive Impairment for Dementia The Influence of Case Definition and Age
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DOI：
10.1159/000200465
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发表时间：
2009-01-01
影响因子：
2.4
通讯作者：
Jolles, J.
中科院分区：
文献类型：
--
作者：
Baars, M. A. E.;van Boxtel, M. P. J.;Jolles, J.
背景/目的：在人群研究中，不同的轻度认知障碍（MCI）定义已被用于预测后期痴呆。本研究比较了不同MCI定义对痴呆的预测值，并探讨了年龄对预测值的影响。方法：本研究是一项正在进行的纵向研究的一部分，研究认知衰老的决定因素，即马斯特里赫特衰老研究。结果：当考虑多个认知领域而不考虑主观抱怨时，MCI最能预测痴呆（敏感性：0.66，特异性：0.78）。年龄对MCI对痴呆的敏感性有很大影响（60-70岁：敏感性= 0.56；70-85岁：敏感性= 0.70）。结论：包括多个认知领域和70岁及以上的参与者，无论主观抱怨如何，都可以最好地预测痴呆。版权所有(C) 2009 S. Karger AG，巴塞尔
Background/Aims: In population studies, different mild cognitive impairment (MCI) definitions have been used to predict dementia at a later stage. This study compared predictive values of different MCI definitions for dementia, and the effect of age on the predictive values was investigated. Methods: This study was conducted as part of an ongoing longitudinal study into the determinants of cognitive aging, the Maastricht Aging Study. Results: MCI best predicted dementia when multiple cognitive domains were considered and subjective complaints were not (sensitivity: 0.66, specificity: 0.78). Age had a strong influence on the sensitivity of MCI for dementia (age 60-70 years: sensitivity = 0.56; age 70-85 years: sensitivity = 0.70). Conclusion: The inclusion of multiple cognitive domains and participants aged 70 years and older leads to the best prediction of dementia, regardless of subjective complaints. Copyright (C) 2009 S. Karger AG, Basel