Are inflammatory factors related to retinal vessel caliber? The Beaver Dam Eye Study
Are inflammatory factors related to retinal vessel caliber? The Beaver Dam Eye Study
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DOI：
10.1001/archopht.124.1.87
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发表时间：
2006-01-01
影响因子：
--
通讯作者：
Tsai, MY
中科院分区：
文献类型：
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作者：
Klein, R;Klein, BEK;Tsai, MY
目的：为了研究炎症，内皮功能障碍，血清叶酸水平视网膜vessel diameter.Methods的全身标志物的关系：横断面分析完成了随机抽样的396人年龄在50至86岁谁接受了基线检查，从1988年至1990年的数据。采用标准化方案进行血液采集和标记物测量。从数字化照片测量微动脉和微静脉的直径。标准的单变量和多变量analysesperformed.Results：而控制年龄，吸烟状况，糖尿病状态，血清高密度脂蛋白胆固醇，红细胞压积，更广泛的视网膜微静脉直径与更高的血清高敏C反应蛋白，白细胞介素6，淀粉样蛋白A水平。在控制年龄、收缩压和舒张压、吸烟、血清高密度脂蛋白胆固醇水平和痛风的同时，较小的小动脉直径与较高的血清淀粉样蛋白A和较低的血清白蛋白和叶酸水平相关，但与高敏C反应蛋白或白细胞介素6水平无关。血清可溶性细胞间粘附分子-1和血清可溶性E-选择素，内皮功能障碍的标志物的水平，与视网膜小动脉或小静脉difficulties.Conclusions：这些数据表明，炎症标志物与较大的视网膜小静脉直径的关联，这表明视网膜小静脉口径可能是全身炎症的标志物。
Objective: To examine the relationship of systemic markers of inflammation, endothelial dysfunction, and serum folate level to retinal vessel diameter.Methods: Cross-sectional analyses were completed for data from a random sample of 396 persons aged 50 to 86 years who underwent a baseline examination from 1988 to 1990. Standardized protocols for blood collection and measurement of markers were used. Diameters of arterioles and venules were measured from digitized photographs. Standard univariate and multivariate analyses were performed.Results: While controlling for age, smoking status, diabetes status, serum high-density lipoprotein cholesterol, and hematocrit, wider retinal venular diameters were associated with higher serum high-sensitivity C-reactive protein, interleukin 6, and amyloid A levels. While controlling for age, systolic and diastolic blood pressure, smoking, serum high-density lipoprotein cholesterol level, and gout, smaller arteriolar diameters were associated with higher serum amyloid A and lower serum albumin and folate levels but not high-sensitivity C-reactive protein or interleukin 6 levels. Levels of serum soluble intercellular adhesion molecule-1 and serum soluble E-selectin, markers of endothelial dysfunction, were not associated with retinal arteriolar or venular diameters.Conclusions: These data show an association of inflammatory markers with larger retinal venular diameter, suggesting that retinal venular caliber may be a marker of systemic inflammation.