Cerebellar direct current stimulation modulates pain perception in humans
Cerebellar direct current stimulation modulates pain perception in humans
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DOI：
10.3233/rnn-140453
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发表时间：
2015-01-01
影响因子：
2.8
通讯作者：
Sartucci, Ferdinando
中科院分区：
文献类型：
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作者：
Bocci, Tommaso;Santarcangelo, Enrica;Sartucci, Ferdinando
目的：小脑参与多种整合功能，但其在疼痛体验和伤害性信息处理中的作用知之甚少。在健康志愿者中，我们评估了经颅小脑直流电刺激（tcDCS）的影响，通过研究在感知阈值的变化，疼痛强度在给定的刺激强度（VAS：0-10）和激光诱发电位（LEPs）变量（N1和N2/P2振幅和laveliments.Methods：15名受试者进行了研究之前和之后的阳极，阴极和假tcDCS。使用钕：钇铝钙钛矿（Nd：雅普）激光获得LEP，并从左手的背部记录。VAS通过两种不同强度的激光脉冲进行评价，分别为感知阈值的2倍和3倍。结果：阴极极化显著降低感知阈值，增加VAS评分，而阳极极化则相反。阴极tcDCS显著增加N1和N2/P2振幅，降低其潜伏期，而阳极tcDCS引起相反的效果。通过经颅磁刺激评估的运动阈值不受小脑stimulation.Conclusions影响：tcDCS调节疼痛感知及其皮质相关。由于它是有效的N1和N2/P2组件，我们推测，小脑参与疼痛处理调制的躯体感觉和扣带皮层的活动。目前的研究结果提示小脑直流极化作为一种可能的新的和安全的治疗工具在慢性疼痛患者的调查。
Purpose: The cerebellum is involved in a wide number of integrative functions, but its role in pain experience and in the nociceptive information processing is poorly understood. In healthy volunteers we evaluated the effects of transcranial cerebellar direct current stimulation (tcDCS) by studying the changes in the perceptive threshold, pain intensity at given stimulation intensities (VAS: 0-10) and laser evoked potentials (LEPs) variables (N1 and N2/P2 amplitudes and latencies).Methods: Fifteen subjects were studied before and after anodal, cathodal and sham tcDCS. LEPs were obtained using a neodymium: yttrium-aluminium-perovskite (Nd: YAP) laser and recorded from the dorsum of the left hand. VAS was evaluated by delivering laser pulses at two different intensities, respectively two and three times the perceptive threshold.Results: Cathodal polarization dampened significantly the perceptive threshold and increased the VAS score, while the anodal one had opposite effects. Cathodal tcDCS increased significantly the N1 and N2/P2 amplitudes and decreased their latencies, whereas anodal tcDCS elicited opposite effects. Motor thresholds assessed through transcranial magnetic stimulation were not affected by cerebellar stimulation.Conclusions: tcDCS modulates pain perception and its cortical correlates. Since it is effective on both N1 and N2/P2 components, we speculate that the cerebellum engagement in pain processing modulates the activity of both somatosensory and cingulate cortices. Present findings prompt investigation of the cerebellar direct current polarization as a possible novel and safe therapeutic tool in chronic pain patients.