Prevalence of hepatitis B or C virus infections in patients with non-Hodgkin's lymphoma
Prevalence of hepatitis B or C virus infections in patients with non-Hodgkin's lymphoma
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DOI：
10.1046/j.1440-1746.2001.02406.x
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发表时间：
2001-02-01
影响因子：
4.1
通讯作者：
Muta, K
中科院分区：
文献类型：
--
作者：
Kuniyoshi, M;Nakamuta, M;Muta, K
背景：丙型肝炎病毒（HCV）和乙型肝炎病毒（HBV）不仅是嗜肝病毒，也是嗜淋巴病毒。最近，一些报道表明，这些病毒可能参与恶性淋巴细胞增生性疾病的发展。方法：我们调查了348例非霍奇金淋巴瘤（NHL）患者HCV或HBV感染的患病率。我们还将这些患病率与作为代表我们地区一般人群的对照组的献血者的患病率进行了比较（n = 1 513 358）。接下来，我们评估了HCV或hbv感染的NHL病例的临床和病理特征。非霍奇金淋巴瘤按照工作配方分类进行分类。结果：HCV、HBV感染37例（14.9%）；其中20例（8.1%）感染HCV， 17例（6.9%）感染HBV。在男性NHL患者中，HCV感染率显著高于同一地区年龄和性别匹配人群（P < 0.001， Mantel-Haenszel检验）。HBV感染率在人群中也有较高的趋势（P = 0.0551）。相反，在女性NHL患者中，HCV或HBV感染率并不高于一般人群。在hcv感染病例中，15例（75%）为b细胞NHL， 16例（80%）为中级；b细胞NHL占所有NHL病例的83%。在hbv感染的NHL病例中，11例（65%）为b细胞型，10例（58%）为中级。结论：在我们的研究人群中，HCV或HBV感染的高流行率提供了流行病学证据，表明HCV和HBV感染可能与男性NHL亚群的发展有关。我们的研究还发现，HCV感染和hbv感染的NHL患者在临床和病理表现上具有一定的相似性。
Background: Hepatitis C virus (HCV) and hepatitis B virus (HBV) are not only hepatotropic, but also lymphotropic viruses. Recently, some reports suggested that these viruses may participate in the development of malignant lymphoproliferative disorders.Methods: We investigated the prevalence of HCV or HBV infection in 348 patients with non-Hodgkin's lymphoma (NHL). We also compared these prevalences with those in blood donors as a control group representing the general population in our area (n = 1 513 358). Next, we evaluated the clinical and pathologic characteristics of HCV- or HBV-infected NHL cases. Non-Hodgkin's lymphoma was classified according to the Working Formulation classification.Results: Thirty-seven cases (14.9%) were found to be infected with HCV or HBV; of these, 20 (8.1%) were infected with HCV, and 17 (6.9%) with HBV. In male NHL patients, the rate of HCV infection was significantly higher than in an age- and sex-matched population in the same area (P < 0.001, Mantel-Haenszel test). The rate of HBV infection also tended to be higher in the population (P = 0.0551). In contrast, in female NHL patients, the rate of HCV or HBV infection was not higher than in the general population. In HCV-infected cases, 15 cases (75%) had B-cell NHL and 16 cases (80%) were classified as being in the intermediate grade; B-cell NHL comprised 83% of all NHL cases. In HBV-infected NHL cases, 11 (65%) were of B-cell type and 10 (58%) were classified as being in the intermediate grade.Conclusions: The high prevalence of HCV or HBV infections in our study population provides epidemiologic evidence suggesting that HCV and HBV infections may be involved in the development of a subgroup of NHL in males. Our investigation also revealed that both HCV- and HBV-infected NHL patients showed certain similarities in clinical and pathologic manifestations.