FETAL AND NEONATAL ERYTHROPOIESIS *
FETAL AND NEONATAL ERYTHROPOIESIS *
复制标题
胎儿和新生儿红细胞生成*
DOI：
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发表时间：
1968
影响因子：
5.2
通讯作者：
F. Stohlman
中科院分区：
文献类型：
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作者：
G. Lucarelli;A. Porcellini;C. Carnevali;A. Carmena;F. Stohlman
成年动物红细胞生成的调节至少部分由肾脏产生的氧依赖性红细胞生成素控制。在啮齿类动物中，对肾脏产生的促红细胞生成素的依赖程度接近绝对值。因此，肾切除的大鼠或小鼠几乎完全抑制红细胞的产生。氧供需关系的变化已被证明对红细胞生成率有深远的影响。然而，值得注意的是，这种扰动在高级哺乳动物中^^，^并不像在啮齿动物中那样引起红细胞生成的显著变化。关于胎儿和新生儿生命中红细胞生成的调节是否与“a d ~ l t“的调节相同，已经提出了一个问题。为了回答这个问题，已经在胎儿和新生大鼠中研究了红细胞生成子的进化及其调节，与出生时的人类相比，这是一种相对不成熟的动物，并且在豚鼠中，出生时成熟度接近人类的动物。这些数据将被简要地总结，并在其他地方进行广泛的评论。
The regulation of red cell production in the adult animal has been shown to be governed, at least in part, by oxygen-dependent erythropoietin production by the ‘kidney. In rodents the degree of dependency on renally produced erythropoietin approaches the absolute.’ Thus the nephrectomized rat or mouse has almost complete suppression of red cell production. Changes in the oxygen supplydemand relationship have been shown to have a profound effect upon the rate of erythropoiesis. It is to be noted, however, that such perturbations in high order mammal^^,^ do not produce as marked a change in red cell production as that in the rodent. The question has been raised as to whether regulation of erythropoiesis in fetal and neonatal life is the same as that for the “ a d ~ l t ” ~ TO answer this question, the evolution of the erythron and its regulation have been studied in the fetal and neonatal rat, which is a relatively immature animal in comparison with human beings at birth, and in the guinea pig, an animrl.1 in which the degree of maturity at birth approaches that of the human being. These data will be briefly summarized and are reviewed extensively e l~ewhere .~