Cytarabine and its effect on cerebellum of suckling mouse.
Cytarabine and its effect on cerebellum of suckling mouse.
复制标题
阿糖胞苷及其对乳鼠小脑的影响。
DOI：
10.1001/archneur.1975.00490500075009
复制
发表时间：
1975
影响因子：
--
通讯作者：
T. Kusonoki
中科院分区：
文献类型：
--
作者：
M. Shimada;S. Wakaizumi;Y. Kasubuchi;T. Kusonoki
乳鼠在出生后2、3和4天皮下注射30 mg/kg或50 mg/kg体重阿糖胞苷。最后一次注射后24小时，这些小鼠显示小脑外颗粒层中未分化细胞的广泛坏死。一两周后，一个新的外部颗粒层再生，但它只是不完全和区域性的。允许活得更长的小鼠表现出小脑功能受损、小脑发育不全和其他畸形，包括分子层中的异位颗粒细胞、不规则排列的浦肯野细胞和内部颗粒层中的细胞稀少。
Suckling mice were injected with 30 mg/kg or 50 mg/kg body weight of cytarabine subcutaneously two, three, and four days after birth. Twenty-four hours after the final injection, these mice showed extensive necrosis of undifferentiated cells in the external granular layer of cerebellum. One or two weeks later, a new external granular layer regenerated but it did so only incompletely and regionally. The mice allowed to live longer showed impaired cerebellar function, cerebellar hypoplasia, and other malformations, including heterotopic granule cells in the molecular layer, irregularly arranged Purkinje cells, and scanty cellularity in the internal granular layer.