In Situ Measurements of Polymer Micellization Kinetics with Millisecond Temporal Resolution
In Situ Measurements of Polymer Micellization Kinetics with Millisecond Temporal Resolution
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DOI：
10.1021/acs.macromol.8b02257
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发表时间：
2019-05-14
期刊：
影响因子：
5.5
通讯作者：
Liu, Ying
中科院分区：
文献类型：
--
作者：
Kalkowski, Joseph;Liu, Chang;Liu, Ying
利用同步辐射小角X射线散射（SAXS）技术和微流控装置，以毫秒级时间分辨率和微米级空间分辨率，对聚乙二醇-B-聚己内酯嵌段共聚物的胶束化动力学进行了原位测量。直接观察到聚合物胶团化、成核、融合和插入的演变规律。五入口微流体装置提供聚合物溶液和反溶剂的稳定连续混合。溶剂置换主要由横向扩散通过流体动力学集中的中心层，其厚度可以精确地设计和操纵的质量平衡的分区流。了解聚合物的胶束化动力学对于自组装聚合物纳米结构的设计和优化至关重要。将SAXS与微流体设备集成的技术可以被移植到其他系统以用于广泛的应用。
Utilizing synchrotron small-angle X-ray scattering (SAXS) integrated with a microfluidic device, micellization kinetics of a diblock co-polymer, poly(ethylene glycol)-b- poly(caprolactone), was measured in situ with millisecond temporal and micrometer spatial resolution. The evolutionary regimes of polymer micellization, nucleation, fusion, and insertion were directly observed. The five-inlet microfluidic device provided steady continuous mixing of the polymer solution and the antisolvent. The solvent replacement was mainly dominated by lateral diffusion across the hydrodynamically focused central layer, whose thickness could be precisely designed and manipulated from the mass balance of the partitioning streams. Knowing the micellization kinetics of the polymers is essential for the design and optimization of self-assembled polymeric nanostructures. The technique of integrating SAXS with microfluidic devices can be translatable to other systems for a breadth of applications.