The disappearance kinetics and glomerular deposition of small-latticed soluble immune complexes.
The disappearance kinetics and glomerular deposition of small-latticed soluble immune complexes.
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DOI：
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发表时间：
1982-11
期刊：
影响因子：
6.4
通讯作者：
A. O. Haakenstad;G. Striker;M. Mannik
中科院分区：
文献类型：
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作者：
A. O. Haakenstad;G. Striker;M. Mannik
在小鼠中检测了抗原过量50倍制备的人血清白蛋白（HSA）抗HSA复合物的消失和肾小球定位，并与抗原过量5倍制备的复合物的相同特征进行了比较。抗原过量50倍制备的复合物主要由小晶格复合物（Ag2Ab2和Ag1Ab1）组成，这些复合物在最初因外渗而迅速消失后仍在循环中持续存在。在96小时的循环中，小晶格复合物的存在并没有导致复合物的肾小球定位。相反，当注射以5倍抗原过量制备的大晶格可溶性复合物时，形成了丰富的肾小球沉积物。这些观察结果表明，循环免疫复合物的晶格必须超过Ag2Ab2结构，才能发生肾小球沉积。
The disappearance from circulation and the glomerular localization of human serum albumin (HSA) anti-HSA complexes made at fifty-fold antigen excess were examined in mice and compared with the same features of complexes made at five-fold antigen excess. Complexes prepared at fifty-fold antigen excess consisted principally of small-latticed complexes (Ag2Ab2 and Ag1Ab1) that persisted in the circulation after the initial rapid disappearance attributed to extravasation. The presence of small-latticed complexes in the circulation did not lead to glomerular localization of complexes during a 96 hr period. In contrast, when large-latticed soluble complexes, prepared at five-fold antigen excess, were injected, abundant glomerular deposits developed. These observations indicate that the lattice of circulating immune complexes must exceed the Ag2Ab2 structure in order for glomerular deposition to occur.