Blood Transfusion: An Independent Risk Factor for Postinjury Multiple Organ Failure
Blood Transfusion: An Independent Risk Factor for Postinjury Multiple Organ Failure
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输血：损伤后多器官衰竭的独立危险因素
DOI：
10.1001/archsurg.1997.01430300062013
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发表时间：
1997
影响因子：
--
通讯作者：
A. Sauaia
中科院分区：
文献类型：
--
作者：
F. Moore;Ernest E. Moore;A. Sauaia
目的：确定输血是否是创伤后多器官功能衰竭（MOF）的一个一致的危险因素，独立于其他休克指标。设计：一项为期55个月的初始队列研究，于1995年8月30日结束。前瞻性收集损伤后MOF的特征数据。对5组数据进行多因素Logistic回归分析。第1组包括入院数据（年龄、性别、合并症、损伤机制、格拉斯哥昏迷评分、损伤严重程度评分和急诊室测定的收缩压）以及前12小时内的输血量。在随后的4个数据集中，依次添加了其他休克指标（早期碱缺乏、早期乳酸水平、晚期碱缺乏和晚期乳酸水平）。此外，以早期MOF和晚期MOF作为结局变量进行相同的多元logistic回归分析。地点：丹佛总医院，丹佛，科洛，是一个地区一级创伤中心。患者：连续513例创伤患者入住创伤重症监护室，损伤严重度评分大于15，年龄大于16岁，存活时间超过48小时。干预措施：无。主要观察指标：输血和其他休克指标与结局变量MOF的关系。结果：早期输血与后期发生MOF之间存在剂量-反应关系。尽管包括其他休克指标，输血被确定为一个独立的危险因素，在15个多元逻辑回归模型中的13个测试;比值比很高，特别是在早期的MOF模型。结论：输血是创伤后MOF的早期一致性危险因素，与休克的其他指标无关。《外科学》1997;132：620-625
Objective: To determine if blood transfusion is a consistent risk factor for postinjury multiple organ failure (MOF), independent of other shock indexes. Design: A 55-month inception cohort study ending on August 30, 1995. Data characterizing postinjury MOF were prospectively collected. Multiple logistic regression analysis was performed on 5 sets of data. Set 1 included admission data (age, sex, comorbidity, injury mechanism, Glasgow Coma Scale, Injury Severity Score, and systolic blood pressure determined in the emergency department) plus the amount of blood transfused within the first 12 hours. In the subsequent 4 data sets, other indexes of shock (early base deficit, early lactate level, late base deficit, and late lactate level) were sequentially added. Additionally, the same multiple logistic regression analyses were performed with early MOF and late MOF as the outcome variables. Setting: Denver General Hospital, Denver, Colo, is a regional level I trauma center. Patients: Five hundred thirteen consecutive trauma patients admitted to the trauma intensive care unit with an Injury Severity Score greater than 15 who were older than 16 years and who survived longer than 48 hours. Interventions: None. Main Outcome Measures: The relationship of blood transfusions and other shock indexes with the outcome variable, MOF. Results: A dose-response relationship between early blood transfusion and the later development of MOF was identified. Despite the inclusion of other indexes of shock, blood transfusion was identified as an independent risk factor in 13 of the 15 multiple logistic regression models tested; the odds ratios were high, especially in the early MOF models. Conclusion: Blood transfusion is an early consistent risk factor for postinjury MOF, independent of other indexes of shock. Arch Surg. 1997;132:620-625
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DOI：
10.1001/archsurg.1992.01420020045007
发表时间：
1992
期刊：
Archives of surgery (Chicago, Ill. : 1960)
影响因子：
--
作者：
Cerra,FB;Maddaus,MA;Dunn,DL;Wells,CL;Konstantinides,NN;Lehmann,SL;Mann,HJ
通讯作者：
Mann,HJ
DOI：
10.1097/00005373-199509000-00003
发表时间：
1995-09
期刊：
The Journal of trauma
影响因子：
--
作者：
Abraham J. Botha;F. Moore;Ernest E. Moore;A. Sauaia;A. Banerjee;V. Peterson
通讯作者：
Abraham J. Botha;F. Moore;Ernest E. Moore;A. Sauaia;A. Banerjee;V. Peterson
DOI：
--
发表时间：
1996-05
期刊：
New horizons
影响因子：
--
作者：
D. Partrick;F. Moore;Ernest E. Moore;C. Barnett;C. Silliman
通讯作者：
D. Partrick;F. Moore;Ernest E. Moore;C. Barnett;C. Silliman
血液常规储存过程中形成并启动中性粒细胞 NADPH 氧化酶的脂质的部分特征。
DOI：
--
发表时间：
1994
期刊：
The Journal of laboratory and clinical medicine
影响因子：
--
作者：
Silliman,CC;Clay,KL;Thurman,GW;Johnson,CA;Ambruso,DR
通讯作者：
Ambruso,DR
影响因子：
3.8
作者：
BOTHA, AJ;MOORE, FA;PETERSON, VM
通讯作者：
PETERSON, VM