MANAGEMENT OF COEXISTING HODGKINS-DISEASE AND PREGNANCY
MANAGEMENT OF COEXISTING HODGKINS-DISEASE AND PREGNANCY
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DOI：
10.1097/00000421-198604000-00009
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发表时间：
1986-04-01
影响因子：
2.6
通讯作者：
KUTCHER, GJ
中科院分区：
文献类型：
--
作者：
NISCE, LZ;TOME, MA;KUTCHER, GJ
活动性霍奇金病（H.D.）孕妇的管理应根据分期、是否有子宫下受累和孕龄进行个体化治疗。17名年龄在16-31岁的女性，同时患有H.D. 1969年至1982年期间，H.D. 15名患者在怀孕期间被诊断，2名患者在治疗期间怀孕。7名妇女的怀孕被允许进行不间断的辐射到pradiphagmatic网站的剂量为1500 - 2000拉德在第二或第三季度，所有足月自然正常分娩和正常婴儿。胎儿剂量范围为2-50拉德。在三次妊娠期间接受长春碱治疗的两名患者分娩了正常足月婴儿。6例患者在妊娠6-10周时因各种原因中断妊娠。尽管确定性治疗的开始延迟了几个月，但H.D.在大多数不间断妊娠中没有受到不利影响，7名接受辐射的患者中有4名患者长期无病生存6-11年，这证明了这一点;现在6-11岁的儿童也活着，并报告正常。
The management of pregnant women with active Hodgkin''s disease (H.D.) should be individualized depending on the stage, the presence of infradiaphragmatic involvement, and age of gestation. Seventeen women aged 16-31 years with coexisting H.D. and pregnancy were followed between 1969 and 1982. H.D. was diagnosed during pregnancy in 15 patients and two became pregnant while on treatment. Seven women whose pregnancies were allowed to proceed uninterrupted were irradiated to supradiphragmatic sites to doses of 1,500-2,000 rad during the second or third trimester; all had full term spontaneous normal deliveries and normal infants. Fetal doses ranged from 2-50 rad. Two patients treated with Vinblastine throughout three pregnancies delivered normal full term infants. Pregnancy was interrupted in six patients at 6-10 weeks of gestation for various reasons. In spite of several months delay in initiation of definitive therapy, the outcome of H.D. was not adversely affected in the majority of uninterrupted pregnancies as evidenced by long term disease-free survivals of 6-11 years in four of seven patients who were irradiated; the children now aged 6-11 years are also alive and reported normal.