Decreased secretion of cortisol and ACTH after oral clonidine administration in normal adults.
Decreased secretion of cortisol and ACTH after oral clonidine administration in normal adults.
复制标题
正常成人口服可乐定后皮质醇和 ACTH 的分泌减少。
DOI：
10.1016/0026-0495(83)90026-4
复制
发表时间：
1983
期刊：
影响因子：
--
通讯作者：
G. Moncada
中科院分区：
文献类型：
--
作者：
R. Lanes;A. Herrera;A. Palacios;G. Moncada
可乐定是一种选择性去甲肾上腺素能受体激动剂，对多种激素有明显的作用。它增加动物和人类成人和儿童的生长激素水平。可乐定对促肾上腺皮质激素和皮质醇水平的影响尚不清楚，刺激和抑制作用都有报道。我们发现12名健康成年人单次口服可乐定后血浆皮质醇浓度显著降低，其中6名患者的ACTH水平也降低。口服可乐定后，未观察到FSH、LH或催乳素的变化。我们的数据是兼容的抑制性去甲肾上腺素能机制调节ACTH和皮质醇分泌正常成人。
Clonidine, a selective noradrenergic receptor agonist, has been shown to affect various hormones acutely. It increases growth hormone levels in animals and in human adults and children. The effect of clonidine upon ACTH and cortisol levels is not as clear, and both stimulatory and inhibitory effects have been reported. We found a significant decrease in plasma cortisol concentrations after a single oral dose of clonidine in 12 healthy adults; ACTH levels measured in six of our patients also decreased. No changes in FSH, LH, or prolactin were seen after oral clonidine. Our data are compatible with an inhibitory noradrenergic mechanism modulating ACTH and cortisol secretion in normal adults.