Successful treatment of human granulocytic ehrlichiosis in children using rifampin
Successful treatment of human granulocytic ehrlichiosis in children using rifampin
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DOI：
10.1542/peds.112.3.e252
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发表时间：
2003-09-01
期刊：
影响因子：
8
通讯作者：
Bakken, JS
中科院分区：
文献类型：
--
作者：
Krause, PJ;Corrow, CL;Bakken, JS
人粒细胞埃立克体病（HGE）是由嗜吞噬细胞无形体（Anaplasma phagocytophilum）引起的一种蜱媒传染病。临床特征包括流感样疾病，通常在1周内消退。可能发生更严重的感染，需要住院治疗或最终死亡。强力霉素是治疗HGE的首选，但可能会导致8岁以下儿童的牙齿永久染色。我们报告成功治疗HGE与利福平在2名儿童，4和6岁。对于8岁以下发生非危及生命的A型嗜吞噬细胞菌感染的儿童，应考虑使用利福平5 - 7天。
Human granulocytic ehrlichiosis (HGE) is an emerging tick-borne infectious disease caused by Anaplasma phagocytophilum. Clinical features include a flu-like illness that usually resolves within 1 week. More serious infection may occur that requires hospital admission or culminates in death. Doxycycline is the treatment of choice for HGE but may cause permanent staining of teeth in children younger than 8 years of age. We report successful treatment of HGE with rifampin in 2 children, 4 and 6 years old. A course of rifampin for 5 to 7 days should be considered in children younger than 8 years of age who experience non-life-threatening A phagocytophilum infection.