Body mass index is associated with leukotriene inflammation in asthmatics
Body mass index is associated with leukotriene inflammation in asthmatics
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DOI：
10.1111/j.1365-2362.2010.02371.x
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发表时间：
2011-01-01
影响因子：
5.5
通讯作者：
Loukides, Stelios
中科院分区：
文献类型：
--
作者：
Giouleka, Paschalina;Papatheodorou, Georgios;Loukides, Stelios
背景：肥胖和哮喘的特点是存在炎症。瘦素和脂联素是由脂肪组织产生的循环激素，调节几种代谢和炎症功能。我们的目的是确定肥胖是否影响哮喘炎症，以及瘦素或/和脂联素在哮喘和肥胖相关炎症之间的可能联系中的作用。材料与方法对100例哮喘患者和60例健康对照者进行研究。患有可能干扰拟议测试的合并症的受试者被排除在外。根据世界卫生组织现行国际体重指数（BMI）分类标准，将所有受试者分为正常范围、肥胖前期和肥胖三组。通过BMI评估表达气道炎症、支气管高反应性、全身性炎症和肥胖的变量之间可能存在的关联。瘦素和脂联素也被测量，并与哮喘、气道和全身炎症变量相关，以阐明可能的关联。结果肥胖患者尿LTE4/肌酐值明显高于肥胖前和正常范围。在线性回归模型中，唯一显著的关联是BMI和尿中LTE4/肌酐之间的关联。使用相同的模型，对数瘦素和对数脂联素分别与尿中LTE4/肌酐呈正相关和负相关。在患者和健康受试者中均未观察到其他显著相关性。结论在一个选定的哮喘患者队列中，肥胖与尿白三烯水平升高显著相关。肥胖哮喘患者瘦素/脂联素平衡的改变可能与白三烯炎症的存在有关。
P>BackgroundObesity and asthma are characterized by the presence of inflammation. Leptin and adiponectin are circulating hormones produced by adipose tissue that regulate several metabolic and inflammatory functions. We aimed to determine whether obesity influences asthmatic inflammation as well as the contribution of leptin or/and adiponectin to a possible linkage between asthmatic and obesity-related inflammation.Materials and methodsOne hundred patients with asthma and 60 healthy controls were studied. Subjects who had a comorbid illness that could interfere with the proposed tests were excluded. All subjects were divided into three groups (normal range, pre-obese, obese) according to the criteria of the current WHO international classification for body mass index (BMI). Possible associations between variables expressing airway inflammation, bronchial hyper-responsiveness, systemic inflammation and obesity, as assessed by BMI, were evaluated. Leptin and adiponectin were also measured and were associated with asthma airway and systemic inflammatory variables to elucidate possible associations.ResultsObese patients had significant higher values of LTE4/creatinine in urine compared with pre-obese and normal range ones. In a linear regression model, the only significant associations were those between BMI and LTE4/creatinine in urine. Using the same model, log leptin and log adiponectin presented positive and negative associations, respectively with LTE4/creatinine in urine. No other significant associations were observed in both patients and healthy subjects.ConclusionsIn a selected cohort of asthmatic patients, obesity is significantly associated with increased urinary leukotriene levels. Alterations of leptin/adiponectin balance may be related to the presence of leukotriene inflammation in obese asthmatic patients.