Association of neuropeptide Y receptor Y5 polymorphisms with dyslipidemia in Mexican Americans
Association of neuropeptide Y receptor Y5 polymorphisms with dyslipidemia in Mexican Americans
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DOI：
10.1038/oby.2007.610
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发表时间：
2007-04-01
期刊：
影响因子：
6.9
通讯作者：
Jenkinson, Christopher P.
中科院分区：
文献类型：
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作者：
Coletta, Dawn K.;Schneider, Jennifer;Jenkinson, Christopher P.
我们检查了神经肽 Y 受体 Y5 (NPY5R) 单核苷酸多态性 (SNP) 与胰岛素抵抗（代谢）综合征指标的遗传关联。我们对来自圣安东尼奥家族糖尿病研究的 27 个家系的 439 名墨西哥裔美国人（年龄 = 43.3 +/- 17.3 岁，BMI = 30.0 +/- 6.7 kg/m(2)）的 10 NPY5R SNP 进行了基因分型，并使用序列寡基因连锁分析程序 (SOLAR) 中实施的测量基因型方法进行关联分析。 NPY5R SNP 的 5 个次要等位基因（rs11100493、rs12501691、P1.rs11100494、rs12512687）被发现与空腹血浆甘油三酯浓度和高密度脂蛋白浓度降低显着相关（p < 0.05）。此外，SNP P2 的次要等位基因与 P 细胞功能稳态模型评估降低 (HOMA-%beta) 显着相关 (p = 0.031)。 SNP 对之间的连锁不平衡表明五个 SNP（rs11100493、rs12501691、P1、rs11100494、rs12512687）的一个单倍型块高度相关（r(2) > 0.98）。这些初步结果为 NPY5R 基因中的 SNP 与墨西哥裔美国人人群中的血脂异常（甘油三酯浓度升高和高密度脂蛋白水平降低）之间的关联提供了证据。
We examined the genetic association of neuropeptide Y receptor Y5 (NPY5R) single nucleotide polymorphisms (SNPs) with measures of the insulin resistance (metabolic) syndrome. We genotyped 10 NPY5R SNPs in 439 Mexican American individuals (age = 43.3 +/- 17.3 years and BMI = 30.0 +/- 6.7 kg/m(2)) distributed across 27 pedigrees from the San Antonio Family Diabetes Study and performed association analyses using the measured genotype approach as implemented in Sequential Oligogenic Linkage Analysis Routines (SOLAR). Minor alleles for five (rs11100493, rs12501691, P1. rs11100494, rs12512687) of the NPY5R SNPs were found to be significantly (p < 0.05) associated with fasting plasma trilglyceride concentrations and decreased high-density lipoprotein concentrations. In addition, the minor allele for SNP P2 was significantly associated (p = 0.031) with a decreased homeostasis model assessment of P-cell function (HOMA-%beta). Linkage disequilibrium between SNP pairs indicated one haplotype block of five SNPs (rs11100493, rs12501691, P1, rs11100494, rs12512687) that were highly correlated (r(2) > 0.98). These preliminary results provide evidence for association of SNPs in the NPY5R gene with dyslipidemia (elevated triglyceride concentrations and reduced high-density lipoprotein levels) in our Mexican American population.