Effects of Icosapent Ethyl on Total Ischemic Events From REDUCE-IT
Effects of Icosapent Ethyl on Total Ischemic Events From REDUCE-IT
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DOI：
10.1016/j.jacc.2019.02.032
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发表时间：
2019-06-11
影响因子：
24
通讯作者：
Ballantyne, Christie M.
中科院分区：
文献类型：
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作者：
Bhatt, Deepak L.;Steg, Ph Gabriel;Ballantyne, Christie M.
在首次事件发生时间分析中，在接受他汀类药物治疗的甘油三酯升高患者中，二十碳五烯酸乙酯显著降低了缺血性事件（包括心血管死亡）的风险。方法REDUCE-IT（减少心血管事件与Icosapent Ethyl干预试验）随机分组8，179例他汀类药物治疗的患者，甘油三酯>= 135和40，
BACKGROUND In time-to-first-event analyses, icosapent ethyl significantly reduced the risk of ischemic events, including cardiovascular death, among patients with elevated triglycerides receiving statins. These patients are at risk for not only first but also subsequent ischemic events.OBJECTIVES Pre-specified analyses determined the extent to which icosapent ethyl reduced total ischemic events.METHODS REDUCE-IT (Reduction of Cardiovascular Events with Icosapent Ethyl-Intervention Trial) randomized 8,179 statin-treated patients with triglycerides >= 135 and 40 and