A parsimonious description of global functional brain organization in three spatiotemporal patterns
A parsimonious description of global functional brain organization in three spatiotemporal patterns
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DOI：
10.1038/s41593-022-01118-1
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发表时间：
2022-07-28
影响因子：
25
通讯作者：
Keilholz, Shella D.
中科院分区：
文献类型：
--
作者：
Bolt, Taylor;Nomi, Jason S.;Keilholz, Shella D.
功能性核磁共振信号的全脑组织已经以无数种方式进行了研究。对这些信号的深入研究表明，这些信号具有少量时空模式的简洁描述。静息状态功能磁共振成像（MRI）对人类大脑的大规模组织产生了看似不同的见解。大脑的大规模组织可以分为两大类：功能连接结构的零滞后表征和行波或传播结构的时滞表征。在本研究中，我们试图以驻波和行波动力学混合组成的三种低频时空模式的形式统一这两类观测现象。结果表明，功能连接梯度、任务正/负反相关模式、全局信号、时滞传播模式、准周期模式和功能连接体网络结构等一系列经验现象都是这三种时空模式的表现。这些模式在很大程度上解释了功能连通性分析背后的整体空间结构，并统一了静息状态功能MRI中以前认为不同的现象。
The whole-brain organization of functional MRI signals has been studied in myriad ways. An in-depth study of these signals suggests a parsimonious description with a small number of spatiotemporal patterns.Resting-state functional magnetic resonance imaging (MRI) has yielded seemingly disparate insights into large-scale organization of the human brain. The brain's large-scale organization can be divided into two broad categories: zero-lag representations of functional connectivity structure and time-lag representations of traveling wave or propagation structure. In this study, we sought to unify observed phenomena across these two categories in the form of three low-frequency spatiotemporal patterns composed of a mixture of standing and traveling wave dynamics. We showed that a range of empirical phenomena, including functional connectivity gradients, the task-positive/task-negative anti-correlation pattern, the global signal, time-lag propagation patterns, the quasiperiodic pattern and the functional connectome network structure, are manifestations of these three spatiotemporal patterns. These patterns account for much of the global spatial structure that underlies functional connectivity analyses and unifies phenomena in resting-state functional MRI previously thought distinct.