Towards a cure for food allergy.
Towards a cure for food allergy.
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寻求治愈食物过敏。
DOI：
10.1016/j.coi.2008.09.002
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发表时间：
2008
影响因子：
7
通讯作者：
Sampson,HughA
中科院分区：
文献类型：
--
作者：
Skripak,JustinM;Sampson,HughA
在过去的二十年里，食物过敏变得更加普遍和持久。到目前为止，这个新兴的问题还没有得到任何治疗选择，患者必须尝试避免已知的过敏性食物，并使用“按需”药物治疗任何过敏反应。食物过敏有许多有前途的新兴治疗方式，包括过敏原特异性和过敏原非特异性免疫方法。虽然过敏原特异性方法有一些明显的差异，但它们都试图通过粘膜途径（口服耐受诱导）将患者暴露于过敏原来诱导耐受。过敏原非特异性方法包括抑制游离总IgE水平的生物制剂（例如抗IgE抗体）或诱导更广泛的免疫抑制（中草药）。
Over the past two decades, food allergies have become both more prevalent and long lasting. This burgeoning problem has not been met with any therapeutic options to date, and patients must attempt to avoid known allergenic foods and treat any allergic reactions with ‘as-needed’ medications. There are a number of promising emerging therapeutic modalities for food allergy, including allergen-specific and allergen non-specific immunotherapeutic approaches. Although the allergen-specific approaches have some distinct differences, they all attempt to induce tolerance by exposing the patient to an allergen via the mucosal route (oral tolerance induction). Allergen non-specific approaches include biologics to suppress free total IgE levels (e.g. anti-IgE antibody) or to induce more general immune suppression (Chinese herbal medication).