Mid-life adiposity factors relate to blood-brain barrier integrity in late life
Mid-life adiposity factors relate to blood-brain barrier integrity in late life
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DOI：
10.1111/j.1365-2796.2007.01869.x
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发表时间：
2007-12-01
影响因子：
11.1
通讯作者：
Blennow, K.
中科院分区：
文献类型：
--
作者：
Gustafson, D. R.;Karlsson, C.;Blennow, K.
Objective.我们探讨了中年时测量的肥胖因素与晚年时通过脑脊液/血清（CSF/S）白蛋白比值测量的血脑屏障（BBB）完整性之间的关系。肥胖因素包括体重指数、性激素结合球蛋白（SHBG）和瘦素的血液水平。在一项纵向研究中进行了超过24年的回顾性分析。基于人口的样本。81名妇女。主要结果指标。CSF/S白蛋白比值。在70-84岁时测量的CSF/S白蛋白比值在超重或肥胖的女性中更高（6.50 +/- 2.79 vs. 5.23 +/- 1.61，年龄校正P = 0.012），并且与46-60岁时的SHBG呈负相关（年龄校正r =-0.321，P < 0.005）。在逐步回归模型中，SHBG预测CSF/S白蛋白比值（β =-0.017，R-2 = 0.107，P = 0.007）。预测CSF/S白蛋白比值的最佳模型（R-2 = 0.187）包括SHBG、年龄组（46岁与>46岁）、超重或肥胖以及SHBG相互作用的年龄组。即使考虑到其他肥胖因素，中年SHBG水平较低与24岁后女性BBB完整性较差有关。SHBG对于理解大脑健康中的性行为介导机制或作为脂肪组织（最大的内分泌器官）的独立标志物可能很重要。
Objective. We explored the relationship between adiposity factors measured during mid-life and blood-brain barrier (BBB) integrity measured via the cerebrospinal fluid/serum (CSF/S) albumin ratio in late life. Adiposity factors included body mass index and blood levels of sex hormone binding globulin (SHBG) and leptin.Design. Retrospective analyses over 24 years within a longitudinal study.Setting. Population-based sample.Subjects. Eighty-one women.Main outcome measures. CSF/S albumin ratio.Results. The CSF/S albumin ratio measured at age 70-84 years was higher amongst women who were overweight or obese (6.50 +/- 2.79 vs. 5.23 +/- 1.61, age-adjusted P = 0.012), and was inversely correlated with SHBG (age-adjusted r = -0.321, P < 0.005) at age 46-60 years. In stepwise regression models, SHBG predicted the CSF/S albumin ratio (beta = -0.017, R-2 = 0.107, P = 0.007). The best model (R-2 = 0.187) predicting CSF/S albumin ratio included SHBG, age group (age 46 years versus >46), overweight or obesity, and an age group by SHBG interaction.Conclusions. Lower levels of SHBG in mid-life were related to worse BBB integrity in women after 24 years in late life, even considering other adiposity factors. SHBG may be important for understanding sex hormone-mediated mechanisms in brain health or as an independent marker of adipose tissue, the largest endocrine organ.