Comparative effects of flavonoids on the growth, viability and metabolism of a colonic adenocarcinoma cell line (HT29 cells)
Comparative effects of flavonoids on the growth, viability and metabolism of a colonic adenocarcinoma cell line (HT29 cells)
复制标题
DOI：
10.1016/0304-3835(96)04262-0
复制
发表时间：
1996-07-19
期刊：
影响因子：
9.7
通讯作者：
Remsey, C
中科院分区：
文献类型：
--
作者：
Agullo, G;GametPayrastre, L;Remsey, C
本研究的目的是比较五类结构的黄酮类化合物对结肠腺癌细胞系（HT29细胞）的活力和代谢的影响。有利于黄酮类化合物细胞毒活性及其抑制乳酸释放能力的最显著结构特征似乎是2，3键的不饱和以及B环的连接位置。实际上，黄酮醇和黄酮是最有效的，并且在这两类中，效力顺序可由羟基或甲氧基取代基调节。另一方面，在我们的模型中，我们未发现黄酮类化合物结构与其调节环磷腺苷（cAMP）水平的能力之间存在任何相关性。对最后这一点进行了讨论。
The aim of the present study was to compare the effect of five structural classes of flavonoids on the viability and metabolism of a colonic adenocarcinoma cell line (HT29 cells). The most prominent structural features of flavonoids favoring both their cytotoxic activity and their capacity to inhibit lactate release appear to be the desaturation of the 2, 3 bond and the position of attachment of the B ring. Indeed, flavonol and flavone are the most potent and, in both classes, the order of potency can be modulated by hydroxyl or methoxyl substituents. On the other hand, in our model, we did not find any correlation between flavonoid structure and their capacity to modulate cAMP level. This last point is discussed.