Ciprofloxacin- and hypocalcemia-induced torsade de pointes triggered by hemodialysis.
Ciprofloxacin- and hypocalcemia-induced torsade de pointes triggered by hemodialysis.
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DOI：
10.1097/00045391-200401000-00014
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发表时间：
2004-01-01
影响因子：
4.2
通讯作者：
Khan, Ijaz A
中科院分区：
文献类型：
--
作者：
Daya, Samantapudi K;Gowda, Ramesh M;Khan, Ijaz A
尖端扭转型室性心动过速是室性心动过速的一种多形性形式，与 QT 间期延长相关，可能是先天性的，也可能是后天性的。获得性形式的病因包括药物作用、低钾血症、低镁血症、低钙血症、饥饿、病态窦房结综合征和房室传导阻滞。我们介绍了一名 76 岁男性，患有急性慢性肾功能衰竭、低钙血症，服用环丙沙星，并伴有血液透析引发的尖端扭转型室性心动过速 QT 间期延长。通过治疗低钙血症纠正了 QT 延长。已知低钙血症和环丙沙星可独立导致 QT 间期延长和尖端扭转型室性心动过速；我们的案例表明，在这种危险因素组合的背景下，透析可能引发扭转型室性心动过速。
Torsade de pointes is a polymorphic form of ventricular tachycardia associated with prolongation of the QT interval, which may be either congenital or acquired. Etiologies for the acquired forms include drug effects, hypokalemia, hypomagnesemia, hypocalcemia, starvation, sick sinus syndrome, and atrioventricular block. We present a 76-year-old man with acute on chronic renal failure, hypocalcemia, on ciprofloxacin, and a prolonged QT interval with torsade de pointes triggered by hemodialysis. The QT prolongation was corrected by treating the hypocalcemia. Hypocalcemia and ciprofloxacin are known to independently cause prolonged QT interval and torsade de pointes; our case illustrates that dialysis can trigger torsade on a background of this risk factor combination.