Integrated Endotoxin Adsorption and Antibacterial Properties of Cationic Polyurethane Foams for Wound Healing
Integrated Endotoxin Adsorption and Antibacterial Properties of Cationic Polyurethane Foams for Wound Healing
复制标题
阳离子聚氨酯泡沫的内毒素吸附和抗菌性能对伤口愈合的综合作用
DOI：
10.1021/acsami.8b19746
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发表时间：
2019-01-23
影响因子：
9.5
通讯作者：
Yan, Feng
中科院分区：
文献类型：
--
作者：
Ding, Yingying;Sun, Zhe;Yan, Feng
Gram-negative bacteria, containing toxic proin-flammatory and pyrogenic substances [endotoxin or lipopolysaccharide (LPS)], can lead to infection and associated serious diseases, such as sepsis and septic shock. Development of antimicrobial materials with intrinsically endotoxin adsorption activity can prevent the release of bacterial toxic components while killing bacteria. Herein, a series of imidazolium-type polyurethane (PU) foams with antimicrobial properties were synthesized. The content effects of cationic moieties on the antimicrobial activities against Gramnegative Escherichia coli and Pseudomonas aeruginosa and Gram-positive Staphylococcus aureus as well as the endotoxin adsorption property were investigated. The obtained PU foams show slightly higher efficiency against two Gram-negative strains than for Gram-positive one and high absorbability of LPS. A wound healing test using P. aeruginosa and its isolated LPS-treated mice as the models further demonstrated that imidazolium-type PU foams combine both antibacterial and endotoxin adsorption properties and may have a potential application as an antimicrobial wound dressing in a clinical setting.
