The facilitative glucose transporter 2: pathophysiological role in mouse and human
The facilitative glucose transporter 2: pathophysiological role in mouse and human
复制标题
促进葡萄糖转运蛋白 2：在小鼠和人类中的病理生理学作用
DOI：
10.1007/978-1-4419-9023-5_12
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发表时间：
2003
期刊：
影响因子：
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通讯作者：
B. Thorens
中科院分区：
文献类型：
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作者：
M. Foretz;B. Thorens
葡萄糖是大多数细胞新陈代谢的重要底物。因为葡萄糖是一种极性分子，它通过生物膜的运输需要特定的转运蛋白。葡萄糖通过肠和肾上皮细胞顶膜的转运依赖于活性Na+/葡萄糖同向转运体SGLT-L和SGLT-2的存在，它们利用Na+离子沿其电化学梯度向下共转运所提供的能量将葡萄糖浓缩在细胞内(Hediger和Rhoads 1994)。葡萄糖通过细胞膜的促进扩散是由葡萄糖载体(蛋白质符号GLUT，溶质载体家族2的基因符号SLC2)催化的，该载体属于运输促进剂超家族，包括有机阴阳离子转运体、酵母己糖转运体、植物己糖/质子转运体和细菌糖/质子转运体(Henderson 1993)。
Glucose is an essential substrate for the metabolism of most cells. Because glucose is a polar molecule, its transport through biological membranes requires specific transporter proteins. Transport of glucose through the apical membrane of intestinal and kidney epithelial cells depends on the presence of active Na+/glucose symporters, SGLT-l and SGLT-2, which concentrate glucose inside the cells using the energy provided by cotransport of Na+ions down their electrochemical gradient (Hediger and Rhoads 1994). Facilitated diffusion of glucose through the cellular membrane is otherwise catalyzed by glucose carriers (protein symbol GLUT, gene symbolSLC2for Solute Carrier Family 2) that belong to a superfamily of transport facilitators which comprises organic anion and cation transporters, yeast hexose transporters, plant hexose/proton symporters, and bacterial sugar/ proton symporters (Henderson 1993).
T.Ito：“线粒体细胞病”Jpn.Circ J.(1989)
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