Amphetamine or cocaine limits the ability of later experience to promote structural plasticity in the neocortex and nucleus accumbens
Amphetamine or cocaine limits the ability of later experience to promote structural plasticity in the neocortex and nucleus accumbens
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DOI：
10.1073/pnas.1834271100
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发表时间：
2003-09-02
影响因子：
11.1
通讯作者：
Robinson, TE
中科院分区：
文献类型：
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作者：
Kolb, B;Gorny, G;Robinson, TE
滥用药物和许多其他种类的经历都具有改变神经树突和脊髓形态的能力，而神经元树突和脊髓是大脑中兴奋性突触的主要部位。因此，我们假设，暴露于精神兴奋剂药物可能会影响后来的经验依赖的结构可塑性。我们用安非他明或可卡因反复治疗大鼠，然后将它们置于复杂环境或标准实验室笼子中3-3.5个月，以此来验证这一假设。对大脑进行高尔基-考克斯染色，并对伏隔核中棘神经元和顶叶锥体细胞上的树突分支数量和树突棘密度进行量化。在大多数测量中，先前使用安非他明或可卡因的治疗干扰了在复杂环境中的体验能力，从而增加树突树突和脊柱密度。我们的结论是，在某些大脑区域，反复暴露于精神运动兴奋剂药物限制了后期经验产生这种形式的突触可塑性的能力，这可能导致与药物滥用相关的持续行为和认知缺陷。
Drugs of abuse and many other kinds of experiences share the ability to alter the morphology of neuronal dendrites and spines, the primary site of excitatory synapses in the brain. We hypothesized, therefore, that exposure to psychostimulant drugs might influence later experience-dependent structural plasticity. We tested this hypothesis by treating rats repeatedly with amphetamine or cocaine and then housing them in either a complex environment or standard laboratory cages for 3-3.5 mo. The brains were processed for Golgi-Cox staining, and the number of dendritic branches and the density of dendritic spines on medium spiny neurons in the nucleus accumbens and pyramidal cells in the parietal cortex were quantified. On most measures, prior treatment with amphetamine or cocaine interfered with the ability of experience in a complex environment to increase dendritic arborization and spine density. We conclude that in some brain regions, repeated exposure to psychomotor-stimulant drugs limits the ability of later experience to produce this form of synaptic plasticity, which may contribute to the persistent behavioral and cognitive deficits associated with drug abuse.