Forskolin lowers intraocular pressure by reducing aqueous inflow.
Forskolin lowers intraocular pressure by reducing aqueous inflow.
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毛喉素通过减少房水流入来降低眼内压。
DOI：
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发表时间：
1984
影响因子：
4.4
通讯作者：
A. Mead
中科院分区：
文献类型：
--
作者：
J. Caprioli;M. Sears;L. Bausher;D. Gregory;A. Mead
Forskolin 是毛喉锦紫苏植物的二萜衍生物，可刺激腺苷酸环化酶活性，而不与细胞表面受体相互作用。毛喉素可降低兔子、猴子和人类的眼内压。在兔子中，房水净流入减少，流出设施保持不变，而睫状血流量增加。每 6 小时一次局部给药，持续 15 天后，兔子没有出现对降低眼压作用的耐受性。体外毛喉素可激活由培养的人睫状上皮或解剖的兔或人眼睫状上皮突起制备的粗颗粒匀浆的腺苷酸环化酶。这种激活不被噻吗洛尔阻断。在毛喉素存在下，异丙肾上腺素对腺苷酸环化酶的体外刺激作用会增强。毛喉素代表一类潜在有用的抗青光眼药物，其分子作用机制与以前使用的药物不同。
Forskolin is a diterpene derivative of the plant Coleus forskohlii that stimulates adenylate cyclase activity without interacting with cell surface receptors. Forskolin lowers the intraocular pressure of rabbits, monkeys, and humans. In rabbits, net aqueous humor inflow decreases, outflow facility remains unchanged, and ciliary blood flow increases. Tolerance to the intraocular pressure lowering effect did not occur in rabbits after topical doses given every 6 hr for 15 days. In vitro forskolin activates adenylate cyclase of crude particulate homogenates prepared from cultured human ciliary epithelia or from dissected ciliary epithelial processes of rabbit or human eyes. This activation is not blocked by timolol. The stimulation of adenylate cyclase by isoproterenol in vitro is potentiated in the presence of forskolin. Forskolin represents a potentially useful class of antiglaucoma agents differing in molecular mechanism of action from previously used drugs.
影响因子：
4.4
作者：
Gregory,D;Sears,M;Bausher,L;Mishima,H;Mead,A
通讯作者：
Mead,A