RADIOIMMUNODETECTION OF COLORECTAL-CARCINOMA WITH IN-111 LABELED MONOCLONAL-ANTIBODY IVP ZCE 025 (A TISSUE CULTURE-PRODUCED ANTI-CEA MAB)
RADIOIMMUNODETECTION OF COLORECTAL-CARCINOMA WITH IN-111 LABELED MONOCLONAL-ANTIBODY IVP ZCE 025 (A TISSUE CULTURE-PRODUCED ANTI-CEA MAB)
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DOI：
10.1097/00006231-199402000-00004
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发表时间：
1994-02-01
影响因子：
1.5
通讯作者：
SCHWEIGHARDT, S
中科院分区：
文献类型：
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作者：
ABDELNABI, H;DOERR, RJ;SCHWEIGHARDT, S
这项前瞻性、非随机I/II期研究的目的是评价组织培养衍生的In-111标记的抗CEA单克隆抗体IVP ZCE 025在原发性、转移性和隐匿性结直肠癌患者中的（1）安全性和（2）检出率。In-111-IVP ZCE 025成像正确识别了37例原发性结直肠癌中的31例，19例热肝转移中的10例，16例远处转移中的11例和7例局部肿瘤复发中的7例。IVP ZCE 025成像在34例患者中的11例中检测到先前未怀疑的肿瘤。4名患者的扫描结果也为真阴性。单克隆抗体剂量为1.0-5.0 mg时IVP ZCE 025的总体性能特征与40.0 mg腹水生产的ZCE 025获得的性能特征相当。61例患者未出现临床或生化不良反应。
The aims of this prospective, nonrandomized phase I/II study were to evaluate (1) the safety and (2) the detection rate of tissue culture-derived, In-111-labelled anti-CEA monoclonal antibody IVP ZCE 025 in patients with primary, metastatic and occult colorectal carcinomas. In-111-IVP ZCE 025 imaging correctly identified 31 of 37 primary colorectal carcinomas, 10 of 19 hot liver metastases, 11 of 16 distant metastases and seven of seven local tumour recurrences. Previously unsuspected tumours were detected by IVP ZCE 025 imaging in 11 of 34 patients. The scans were also true negative in four patients. The overall performance characteristics of IVP ZCE 025 at monoclonal antibody doses of 1.0-5.0 mg were comparable to those obtained with 40.0 mg ascites-produced ZCE 025. No clinical or biochemical adverse reactions were encountered in the 61 patients entered into this study.