Morphogenetic implications of peristaltic fluid-tissue dynamics in the embryonic lung
Morphogenetic implications of peristaltic fluid-tissue dynamics in the embryonic lung
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DOI：
10.1016/j.jtbi.2015.06.022
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发表时间：
2015-10-07
影响因子：
2
通讯作者：
Lubkin, Sharon R.
中科院分区：
文献类型：
--
作者：
Bokka, Kishore K.;Jesudason, Edwin C.;Lubkin, Sharon R.
肺内的蠕动一形成，就开始蠕动，一直持续到出生。由于胎儿期的肺充满液体，所以平滑肌的作用会使组织变形，并将液体输送到远离邻近组织的地方。胚胎组织的伸展和内部液体流动的感觉已被证明具有强大的形态发生效应。我们假设这些效应在肺形态发生中起作用。为了将这一假设置于量化框架中，我们分析了一个模型，该模型描述了胚胎组织和管腔液体之间的流体-结构相互作用，该模型是由蠕动波引起的，蠕动波部分阻塞了呼吸道。我们发现，如果呼吸道关闭，变形是同步的；相反，如果气管开放，最大闭塞先于最大压力。我们对咬合、拉伸和血流如何依赖于组织硬度、平滑肌力、组织形状和大小以及液体粘度进行参数分析。我们发现，这些关系中的大多数都是由简单的比率决定的。(C)2015爱思唯尔有限公司。保留所有权利。
Peristalsis begins in the lung as soon as the smooth muscle forms, and persists until birth. Since the prenatal lung is liquid-filled, smooth muscle action can deform tissues and transport fluid far from the immediately adjacent tissues. Stretching of embryonic tissues and sensation of internal fluid flows have been shown to have potent morphogenetic effects. We hypothesize that these effects are at work in lung morphogenesis. To place that hypothesis in a quantitative framework, we analyze a model of the fluid-structure interactions between embryonic tissues and lumen fluid resulting from peristaltic waves that partially occlude the airway. We find that if the airway is closed, deformations are synchronized; by contrast, if the trachea is open, maximal occlusion precedes maximal pressure. We perform a parametric analysis of how occlusion, stretch, and flow depend on tissue stiffnesses, smooth muscle force, tissue shape and size, and fluid viscosity. We find that most of these relationships are governed by simple ratios. (C) 2015 Elsevier Ltd. All rights reserved.