A rapid and simple cleanup procedure for metathesis reactions
A rapid and simple cleanup procedure for metathesis reactions
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DOI：
10.1021/ol0631399
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发表时间：
2007-03-29
期刊：
影响因子：
5.2
通讯作者：
Diver, Steven T.
中科院分区：
文献类型：
--
作者：
Galan, Brandon R.;Kalbarczyk, Kyle P.;Diver, Steven T.
报道了一种用极性异氰化物从复分解反应中脱除钌的新方法。该方案从各种合成有用的复分解中除去了大多数钌副产物。此外，异氰化物促进的卡宾插入导致卡宾反应性的快速破坏，这在常用的第一代和第二代Grubbs卡宾中得到证明。
A new method for easy removal of ruthenium from metathesis reactions by using a polar isocyanide is reported. This protocol removed most ruthenium byproducts from a variety of synthetically useful metatheses. Moreover, the isocyanide-promoted carbene insertion results in rapid destruction of carbene reactivity, demonstrated in the commonly used first- and second-generation Grubbs' carbenes.