Association between ADIPOQ G276T and C11377G polymorphisms and the risk of non-alcoholic fatty liver disease: An updated meta-analysis
Association between ADIPOQ G276T and C11377G polymorphisms and the risk of non-alcoholic fatty liver disease: An updated meta-analysis
复制标题
ADIPOQ G276T 和 C11377G 多态性与非酒精性脂肪肝疾病风险之间的关联：更新的荟萃分析
DOI：
10.1002/mgg3.624
复制
发表时间：
2019-05-01
影响因子：
2
通讯作者：
Liu, Wanyang
中科院分区：
文献类型：
--
作者：
Liu, Mengwei;Liu, Shan;Liu, Wanyang
背景含酒精脂肪肝疾病（NAFLD）是全球肝疾病的重要贡献者。 ADIPOQ基因单核苷酸多态性与NAFLD敏感性有关，但在整个研究中结果不一致。这项研究旨在调查Adipoq多态性（+276G> T，RS1501299和-11377C> G，RS266729）与NAFLD.Methodspubmed，Embase，Wanfang，Wanfang，Web of Science，以及中国国民知识基础数据库的相关文献的文献。使用Stata 11.0软件和REVMAN 5.2计算统计分析。生成了汇总优势比（OR）和95％的置信区间（CI）来评估关联的强度。含量为3,644名参与者（1,847例/1,797个对照组）的相关文章。 Our meta-analysis results revealed that ADIPOQ gene +276G>T polymorphism was not associated with NAFLD under various genetic models (allele model: OR=0.99, 95% CI [0.69, 1.41]; dominant model: OR=1.06, 95% CI [0.71, 1.58]; recessive model: OR=0.83, 95% CI [0.42, 1.65];纯合模型：OR = 0.86，95％CI [0.38，1.95]；此外，在亚组中没有发现 +276G> t和NAFLD风险之间的统计显着关联。 ADIPOQ gene -11377C>G polymorphism significantly increased the risk of NAFLD (allele model: OR=1.49, 95% CI [1.28, 1.75]; dominant model: OR=1.64, 95% CI [1.35, 1.99]; recessive model: OR=1.77, 95% CI [1.16, 2.70]; homozygous model: OR=2.13, 95％CI [1.38，3.28]杂合模型：OR = 1.58，95％CI [分别为1.29，1.93]。需要进一步的研究来检测这些ADIPOQ多态性与NAFLD之间的关系。
BackgroundNonalcoholic fatty liver disease (NAFLD) is a significant contributor to global hepatic disorders. ADIPOQ gene single-nucleotide polymorphisms have been associated with NAFLD susceptibility, but with inconsistent results across the studies. This study aimed to investigate the association between ADIPOQ polymorphisms (+276G>T, rs1501299 and -11377C>G, rs266729) and the risk of NAFLD.MethodsPubMed, Embase, Wanfang, Web of Science, and China National Knowledge Infrastructure databases were used to identify the relevant published literature. Statistical analyses were calculated with STATA 11.0 software and RevMan 5.2. Summary odds ratios (OR) and 95% confidence intervals (CIs) were generated to assess the strength of the associations.ResultsEleven relevant articles with a total of 3,644 participants (1,847 cases/1,797 controls) were included. Our meta-analysis results revealed that ADIPOQ gene +276G>T polymorphism was not associated with NAFLD under various genetic models (allele model: OR=0.99, 95% CI [0.69, 1.41]; dominant model: OR=1.06, 95% CI [0.71, 1.58]; recessive model: OR=0.83, 95% CI [0.42, 1.65]; homozygous model: OR=0.86, 95% CI [0.38, 1.95]; heterozygous model: OR=1.10, 95% CI [0.80, 1.53]; respectively). Moreover, no statistical significant association was found between +276G>T and NAFLD risk in the subgroups. ADIPOQ gene -11377C>G polymorphism significantly increased the risk of NAFLD (allele model: OR=1.49, 95% CI [1.28, 1.75]; dominant model: OR=1.64, 95% CI [1.35, 1.99]; recessive model: OR=1.77, 95% CI [1.16, 2.70]; homozygous model: OR=2.13, 95% CI [1.38, 3.28]; heterozygous model: OR=1.58, 95% CI [1.29, 1.93]; respectively).ConclusionADIPOQ gene -11377C>G may be a risk factor for NAFLD, while there was no association between ADIPOQ gene +276G>T polymorphism and the risk of NAFLD. Further studies are needed to detect the relationship between these ADIPOQ polymorphisms and NAFLD.