Insulin sensitivity and secretion in normal children related to size at birth, postnatal growth, and plasma insulin-like growth factor-I levels
Insulin sensitivity and secretion in normal children related to size at birth, postnatal growth, and plasma insulin-like growth factor-I levels
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DOI：
10.1007/s00125-004-1405-8
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发表时间：
2004-06-01
期刊：
影响因子：
8.2
通讯作者：
Dunger, DB
中科院分区：
文献类型：
--
作者：
Ong, KK;Petry, CJ;Dunger, DB
目标/假设。 2 型糖尿病风险与低出生体重、儿童期体重快速增加、成人身材矮小和循环 IGF-I 水平较低有关。生长速度的最大变化发生在出生后最初几年。我们假设出生后早期身高和体重增加以及 IGF-I 水平的变化可能与成人疾病的风险标志物相关。方法。我们测量了来自前瞻性出生队列的 851 名正常 8 岁儿童的空腹胰岛素敏感性（稳态模型）和口服葡萄糖后胰岛素分泌（胰岛素生成指数 0-30 分钟）。我们研究了出生时体型、出生后体重增加和循环 IGF-I 水平与 8 岁时胰岛素敏感性和分泌之间的关系。结果。 8 年空腹胰岛素敏感性与当前 BMI 密切相关（r=-0.33，p
Aims/hypothesis. Type 2 diabetes risk is associated with low birth weight, rapid weight gain during childhood, and shorter stature and lower circulating IGF-I levels in adults. The largest variations in growth rates occur during the first postnatal years. We hypothesised that early postnatal variations in height and weight gain and IGF-I levels may be associated with risk markers for adult disease. Methods. We measured the fasting insulin sensitivity (Homeostasis model) and insulin secretion post-oral glucose (insulinogenic index 0-30 min) in 851 normal 8-year-old children from a prospective birth cohort. We examined associations between size at birth, postnatal weight gain and circulating IGF-I levels with insulin sensitivity and secretion at 8 years of age. Results. Fasting insulin sensitivity at 8 years was closely related to current BMI (r=-0.33, p